Nude mouse interim host model for human parathyroid grafts. I. Structure and secretory function.

Human parathyroid (PTG) tissues from cadaver (C-PTG), fetus (F-PTG) and PTG adenoma (A-PTG) were transplanted into the kidney subcapsule of Balb/C nude mice as interim host. The structure and secretory function of the tissues were checked 30, 60, 90, 120, and 150 days after operation. The results showed that PTG tissues from all three donors could retain their structure and secretory function for more than 100 days in the nude mice. The growth and function of PTG tissues from the three donors in nude mice were compared.