| Literature DB >> 14503887 |
Ellen J M van Kan1, Dragomir N Ganchev, Margot M E Snel, Vladimir Chupin, Arie van der Bent, Ben de Kruijff.
Abstract
In this study the interaction of the antimicrobial peptide clavanin A with phosphatidylcholine bilayers is investigated by DSC, NMR, and AFM techniques. It is shown that the peptide interacts strongly and specifically with the lipids, resulting in increased order-disorder phase transition temperatures, phase separation, altered acyl chain and headgroup packing, and a drastically changed surface morphology of the bilayer. These results are interpreted in terms of clavanin-specific interactions with lipids and are discussed in the light of the different mechanisms by which clavanin A can destroy the barrier function of biological membranes.Entities:
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Year: 2003 PMID： 14503887 DOI： 10.1021/bi0349017
Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162