PURPOSE: The pathogenesis of Peyronie's disease remains unclear. Previous studies have described possible associations among various HLAs and Peyronie's disease. However, only small series comprising 9 to 52 patients were analyzed in these studies and published results are controversial. We prospectively investigated a possible association of Peyronie's disease with HLA classes I and II specificity in a large patient group. MATERIALS AND METHODS: A total of 154 consecutive patients with Peyronie's disease were typed serologically for HLA class I antigens. Molecular typing of HLA class II alleles was performed by polymerase chain reaction sequence specific primers. Results were compared with those in healthy bone marrow donors for HLA classes I (2,450) and II (316), serving as representative controls selected from the local population. In addition, HLA distribution in a German normal cohort of 14,835 individuals served as a control. RESULTS: No significant difference in HLA classes I and II antigen frequency was evident in patients with Peyronie's disease compared with healthy controls. CONCLUSIONS: The results of this study do not indicate any significant association between Peyronie's disease and antigens of the HLA system.
PURPOSE: The pathogenesis of Peyronie's disease remains unclear. Previous studies have described possible associations among various HLAs and Peyronie's disease. However, only small series comprising 9 to 52 patients were analyzed in these studies and published results are controversial. We prospectively investigated a possible association of Peyronie's disease with HLA classes I and II specificity in a large patient group. MATERIALS AND METHODS: A total of 154 consecutive patients with Peyronie's disease were typed serologically for HLA class I antigens. Molecular typing of HLA class II alleles was performed by polymerase chain reaction sequence specific primers. Results were compared with those in healthy bone marrow donors for HLA classes I (2,450) and II (316), serving as representative controls selected from the local population. In addition, HLA distribution in a German normal cohort of 14,835 individuals served as a control. RESULTS: No significant difference in HLA classes I and II antigen frequency was evident in patients with Peyronie's disease compared with healthy controls. CONCLUSIONS: The results of this study do not indicate any significant association between Peyronie's disease and antigens of the HLA system.
Authors: Kristina L Allen-Brady; Michael B Christensen; Ashlynn D Sandberg; Alexander W Pastuszak Journal: Andrology Date: 2022-07-13 Impact factor: 4.456
Authors: Ludovic Ferretti; Thomas M Fandel; Xuefeng Qiu; Haiyang Zhang; Hazem Orabi; Alex K Wu; Lia Banie; Guifang Wang; Guiting Lin; Ching-Shwun Lin; Tom F Lue Journal: Asian J Androl Date: 2014 Jul-Aug Impact factor: 3.285