Literature DB >> 14501447

Oral steroid treatment of sudden sensorineural hearing loss: a ten year retrospective analysis.

Chu-Yao Chen1, Chris Halpin, Steven D Rauch.   

Abstract

OBJECTIVE: To describe ten years of experience with Sudden Sensorineural Hearing Loss and compare the outcomes with and without treatment with oral corticosteroids. STUDY
DESIGN: Retrospective review of medical records.
SETTING: Large specialty hospital, Department of Otolaryngology. PATIENTS: Patients presenting with sudden onset (72 hours) unilateral sensorineural hearing loss, with no evidence of Ménière's Disease, acoustic injury, retrocochlear disease, and other specifiable disorders.
INTERVENTIONS: The majority of patients received a standard course of oral corticosteroids (Prednisone 60 mg and taper). A smaller group declined treatment. MAIN OUTCOME MEASURES: Recovery of hearing sensitivity was measured using standard audiometry and reported as change in Pure Tone Average. Word recognition scores were also analyzed.
RESULTS: When severe-to-profound cases are analyzed, a significant improvement (p <.01) in Pure Tone Average is seen in cases treated with steroids versus those untreated. When milder cases are included, a statistical floor effect prevents differentiation of these groups. Word recognition scores were significantly improved (p <.05) in the treated group.
CONCLUSIONS: Application of steroid medication significantly improves the recovery outcomes in cases of Severe Sudden Sensorineural Hearing Loss.

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Year:  2003        PMID: 14501447     DOI: 10.1097/00129492-200309000-00006

Source DB:  PubMed          Journal:  Otol Neurotol        ISSN: 1531-7129            Impact factor:   2.311


  43 in total

1.  Early combination treatment with intratympanic steroid injection in severe to profound sudden sensorineural hearing loss improves speech discrimination performance.

Authors:  Young Ho Kim; Kyung Tae Park; Byung Yoon Choi; Min Hyun Park; Jun Ho Lee; Seung-Ha Oh; Sun O Chang
Journal:  Eur Arch Otorhinolaryngol       Date:  2011-12-08       Impact factor: 2.503

2.  Therapy of hearing disorders - conservative procedures.

Authors:  Stefan Plontke
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2005-09-28

3.  Hearing Changes After Intratympanically Applied Steroids for Primary Therapy of Sudden Hearing Loss: A Meta-analysis Using Mathematical Simulations of Drug Delivery Protocols.

Authors:  Arne Liebau; Olivia Pogorzelski; Alec N Salt; Stefan K Plontke
Journal:  Otol Neurotol       Date:  2017-01       Impact factor: 2.311

4.  Increased levels of mean platelet volume: a possible relationship with idiopathic sudden hearing loss.

Authors:  Sahin Ulu; M Sena Ulu; Ahmet Ahsen; Fatih Yucedag; Abdullah Aycicek; Sefa Celik
Journal:  Eur Arch Otorhinolaryngol       Date:  2013-01-23       Impact factor: 2.503

5.  Audiology in the sudden hearing loss clinical trial.

Authors:  Chris Halpin; Helen Shi; Domenic Reda; Patrick J Antonelli; Seilesh Babu; John P Carey; Bruce J Gantz; Joel A Goebel; Paul E Hammerschlag; Jeffrey P Harris; Brandon Isaacson; Daniel Lee; Chris J Linstrom; Lorne S Parnes; William H Slattery; Steven A Telian; Jeffrey T Vrabec; Steven Rauch
Journal:  Otol Neurotol       Date:  2012-08       Impact factor: 2.311

6.  Evaluation of intratympanic dexamethasone for treatment of refractory sudden sensorineural hearing loss.

Authors:  Yao-wen Wang; Ji-hao Ren; Yong-de Lu; Tuan-fang Yin; Ding-hua Xie
Journal:  J Zhejiang Univ Sci B       Date:  2012-03       Impact factor: 3.066

7.  Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss.

Authors:  Stefan K Plontke; Alexander Glien; Torsten Rahne; Karsten Mäder; Alec N Salt
Journal:  Otol Neurotol       Date:  2014-08       Impact factor: 2.311

8.  Positive family history of idiopathic sudden sensorineural hearing loss.

Authors:  A Gäckler; A K Eickelmann; D Brors; S Dazert; J T Epplen; E Kunstmann
Journal:  Eur Arch Otorhinolaryngol       Date:  2010-07-01       Impact factor: 2.503

9.  Sudden hearing loss: an effectivity comparison of intratympanic and systemic steroid treatments.

Authors:  Gülce Ermutlu; Nilda Süslü; Taner Yılmaz; Sarp Saraç
Journal:  Eur Arch Otorhinolaryngol       Date:  2017-07-29       Impact factor: 2.503

10.  Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress.

Authors:  J C Adams; B Seed; N Lu; A Landry; R J Xavier
Journal:  Neuroscience       Date:  2009-03-11       Impact factor: 3.590

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