BACKGROUND: Suspended particles and ozone have been associated with varying degrees of cardiac autonomic dysfunction. METHODS: In Mexico City, residents from a nursing home underwent heart rate variability analysis every other day for 3 months. Indoor and outdoor PM2.5 (particulate matter less than 2.5 mm in diameter) were measured daily at the nursing home. Levels of ozone and other atmospheric pollutants were obtained from a nearby automated monitoring station. RESULTS: Of the initial 42 screened participants, 34 (81%) were followed during the study period. The 24-hour average levels of indoor PM2.5 ranged from 15 to 67 micro g/m3, and outdoor PM2.5 ranged from 9 to 87 micro g/m3. Daily 1-hour maximum ozone levels ranged from 47 to 228 ppb. After adjusting for age and heart rate, we observed a strong decrease in the high frequency component of heart rate variability and the average 24-hour concentrations of PM2.5. Participants with hypertension had considerably larger reductions in their HF-HRV (high frequency-heart rate variability) component in relation to both ozone and PM2.5 exposure. CONCLUSIONS: Our results suggest that ambient levels of PM2.5 and ozone can reduce the high-frequency component of heart rate variability in elderly subjects living in Mexico City and that subjects with underlying hypertension are particularly susceptible to this effect.
BACKGROUND: Suspended particles and ozone have been associated with varying degrees of cardiac autonomic dysfunction. METHODS: In Mexico City, residents from a nursing home underwent heart rate variability analysis every other day for 3 months. Indoor and outdoor PM2.5 (particulate matter less than 2.5 mm in diameter) were measured daily at the nursing home. Levels of ozone and other atmospheric pollutants were obtained from a nearby automated monitoring station. RESULTS: Of the initial 42 screened participants, 34 (81%) were followed during the study period. The 24-hour average levels of indoor PM2.5 ranged from 15 to 67 micro g/m3, and outdoor PM2.5 ranged from 9 to 87 micro g/m3. Daily 1-hour maximum ozone levels ranged from 47 to 228 ppb. After adjusting for age and heart rate, we observed a strong decrease in the high frequency component of heart rate variability and the average 24-hour concentrations of PM2.5. Participants with hypertension had considerably larger reductions in their HF-HRV (high frequency-heart rate variability) component in relation to both ozone and PM2.5 exposure. CONCLUSIONS: Our results suggest that ambient levels of PM2.5 and ozone can reduce the high-frequency component of heart rate variability in elderly subjects living in Mexico City and that subjects with underlying hypertension are particularly susceptible to this effect.
Authors: F Ballester; P Rodríguez; C Iñíguez; M Saez; A Daponte; I Galán; M Taracido; F Arribas; J Bellido; F B Cirarda; A Cañada; J J Guillén; F Guillén-Grima; E López; S Pérez-Hoyos; A Lertxundi; S Toro Journal: J Epidemiol Community Health Date: 2006-04 Impact factor: 3.710
Authors: Sung Kyun Park; Amy H Auchincloss; Marie S O'Neill; Ronald Prineas; Juan C Correa; Jerry Keeler; R Graham Barr; Joel D Kaufman; Ana V Diez Roux Journal: Environ Health Perspect Date: 2010-06-08 Impact factor: 9.031
Authors: Jeroen J de Hartog; Timo Lanki; Kirsi L Timonen; Gerard Hoek; Nicole A H Janssen; Angela Ibald-Mulli; Annette Peters; Joachim Heinrich; Tuula H Tarkiainen; Rene van Grieken; Joop H van Wijnen; Bert Brunekreef; Juha Pekkanen Journal: Environ Health Perspect Date: 2008-08-25 Impact factor: 9.031
Authors: Antonella Zanobetti; Diane R Gold; Peter H Stone; Helen H Suh; Joel Schwartz; Brent A Coull; Frank E Speizer Journal: Environ Health Perspect Date: 2009-11-18 Impact factor: 9.031