Literature DB >> 14500538

Evaluation of the roles of four Candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus.

Shaoji Cheng1, M Hong Nguyen, Zongde Zhang, Hongyan Jia, Martin Handfield, Cornelius J Clancy.   

Abstract

Reintroducing URA3 to its native locus in Candida albicans not5, not3, bur2, and kel1 disruption mutants enabled us to directly compare strains with control strain CAI-12. We showed that URA3 position affected orotidine 5'-monophosphate decarboxylase activity, hyphal morphogenesis, adherence, and mortality in murine disseminated candidiasis. After URA3 was reintroduced to its native locus, only NOT5 could be conclusively ascribed a role in virulence.

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Year:  2003        PMID： 14500538      PMCID： PMC201070          DOI： 10.1128/IAI.71.10.6101-6103.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  12 in total

Review 1.  URA3 as a selectable marker for disruption and virulence assessment of Candida albicans genes.

Authors:  Janet F Staab; Paula Sundstrom
Journal:  Trends Microbiol       Date:  2003-02       Impact factor: 17.079

2.  Pathogenicity of Candida albicans auxotrophic mutants in experimental infections.

Authors:  D R Kirsch; R R Whitney
Journal:  Infect Immun       Date:  1991-09       Impact factor: 3.441

3.  Directed mutagenesis in Candida albicans: one-step gene disruption to isolate ura3 mutants.

Authors:  R Kelly; S M Miller; M B Kurtz; D R Kirsch
Journal:  Mol Cell Biol       Date:  1987-01       Impact factor: 4.272

4.  Factors affecting the adherence of Candida albicans to human buccal epithelial cells in human immunodeficiency virus infection.

Authors:  C S Tsang; L P Samaranayake
Journal:  Br J Dermatol       Date:  1999-11       Impact factor: 9.302

5.  Isogenic strain construction and gene mapping in Candida albicans.

Authors:  W A Fonzi; M Y Irwin
Journal:  Genetics       Date:  1993-07       Impact factor: 4.562

6.  Reevaluation of the role of HWP1 in systemic candidiasis by use of Candida albicans strains with selectable marker URA3 targeted to the ENO1 locus.

Authors:  Paula Sundstrom; Jim E Cutler; Janet F Staab
Journal:  Infect Immun       Date:  2002-06       Impact factor: 3.441

7.  PRR1, a homolog of Aspergillus nidulans palF, controls pH-dependent gene expression and filamentation in Candida albicans.

Authors:  A Porta; A M Ramon; W A Fonzi
Journal:  J Bacteriol       Date:  1999-12       Impact factor: 3.490

8.  Identification of Candida albicans genes induced during thrush offers insight into pathogenesis.

Authors:  Shaoji Cheng; Cornelius J Clancy; Mary Ann Checkley; Martin Handfield; Jeffrey D Hillman; Ann Progulske-Fox; Alfred S Lewin; Paul L Fidel; M Hong Nguyen
Journal:  Mol Microbiol       Date:  2003-06       Impact factor: 3.501

9.  Altered expression of selectable marker URA3 in gene-disrupted Candida albicans strains complicates interpretation of virulence studies.

Authors:  J Lay; L K Henry; J Clifford; Y Koltin; C E Bulawa; J M Becker
Journal:  Infect Immun       Date:  1998-11       Impact factor: 3.441

10.  PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis.

Authors:  S M Saporito-Irwin; C E Birse; P S Sypherd; W A Fonzi
Journal:  Mol Cell Biol       Date:  1995-02       Impact factor: 4.272
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  43 in total

Review 1.  Milestones in Candida albicans gene manipulation.

Authors:  Dhanushki P Samaranayake; Steven D Hanes
Journal:  Fungal Genet Biol       Date:  2011-04-14       Impact factor: 3.495

2.  Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance.

Authors:  Taiga Miyazaki; Yoshitsugu Miyazaki; Koichi Izumikawa; Hiroshi Kakeya; Shunichi Miyakoshi; John E Bennett; Shigeru Kohno
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

Review 3.  Functional profiling of human fungal pathogen genomes.

Authors:  Alexi I Goranov; Hiten D Madhani
Journal:  Cold Spring Harb Perspect Med       Date:  2014-11-06       Impact factor: 6.915

4.  Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis.

Authors:  Alexandra Correia; Ulrich Lermann; Luzia Teixeira; Filipe Cerca; Sofia Botelho; Rui M Gil da Costa; Paula Sampaio; Fátima Gärtner; Joachim Morschhäuser; Manuel Vilanova; Célia Pais
Journal:  Infect Immun       Date:  2010-08-02       Impact factor: 3.441

5.  Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.

Authors:  Mahmoud Rouabhia; Martin Schaller; Cristina Corbucci; Anna Vecchiarelli; Stephan K-H Prill; Luc Giasson; Joachim F Ernst
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

6.  Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophils.

Authors:  Chen Du; Richard Calderone; John Richert; Dongmei Li
Journal:  Infect Immun       Date:  2005-02       Impact factor: 3.441

7.  CaNAT1, a heterologous dominant selectable marker for transformation of Candida albicans and other pathogenic Candida species.

Authors:  Junqing Shen; Weihui Guo; Julia R Köhler
Journal:  Infect Immun       Date:  2005-02       Impact factor: 3.441

8.  Peroxisomal fatty acid beta-oxidation is not essential for virulence of Candida albicans.

Authors:  Katarzyna Piekarska; Els Mol; Marlene van den Berg; Guy Hardy; Janny van den Burg; Carlo van Roermund; Donna MacCallum; Frank Odds; Ben Distel
Journal:  Eukaryot Cell       Date:  2006-09-08

9.  Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.

Authors:  Suzanne M Noble; Sarah French; Lisa A Kohn; Victoria Chen; Alexander D Johnson
Journal:  Nat Genet       Date:  2010-06-13       Impact factor: 38.330

10.  Host cell invasion and virulence mediated by Candida albicans Ssa1.

Authors:  Jianing N Sun; Norma V Solis; Quynh T Phan; Jashanjot S Bajwa; Helena Kashleva; Angela Thompson; Yaoping Liu; Anna Dongari-Bagtzoglou; Mira Edgerton; Scott G Filler
Journal:  PLoS Pathog       Date:  2010-11-11       Impact factor: 6.823
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