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Literature DB >> 14500533

Serum amyloid P component binding to Shiga toxin 2 requires both a subunit and B pentamer.

Paola Marcato¹, Kathleen Vander Helm, George L Mulvey, Glen D Armstrong.

Abstract

Solid-phase binding, competitive binding, and cytotoxicity neutralization assays indicate that the B pentamer and A subunit both contribute to human serum amyloid P (HuSAP) component binding to Stx2. A polyvalent globotriaosyl-ceramide receptor analog, Daisy, did not competitively inhibit HuSAP binding, implying that the two ligands bind to different Stx2 domains.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2003 PMID： 14500533 PMCID： PMC201105 DOI： 10.1128/IAI.71.10.6075-6078.2003

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

16 in total

1. Role of Shiga toxin 2 (Stx2)-binding protein, human serum amyloid P component (HuSAP), in Shiga toxin-producing Escherichia coli infections: assumption from in vitro and in vivo study using HuSAP and anti-Stx2 humanized monoclonal antibody TMA-15.

Authors: Tsuyoshi Kimura; Shinobu Tani; Masamichi Motoki; Yoh-ichi Matsumoto
Journal: Biochem Biophys Res Commun Date: 2003-06-13 Impact factor: 3.575

2. Induction of cytokines in a human colon epithelial cell line by Shiga toxin 1 (Stx1) and Stx2 but not by non-toxic mutant Stx1 which lacks N-glycosidase activity.

Authors: C Yamasaki; Y Natori; X T Zeng; M Ohmura; S Yamasaki; Y Takeda; Y Natori
Journal: FEBS Lett Date: 1999-01-15 Impact factor: 4.124

3. Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNAs in intestinal epithelial cells, resulting in increased chemokine expression.

Authors: C M Thorpe; W E Smith; B P Hurley; D W Acheson
Journal: Infect Immun Date: 2001-10 Impact factor: 3.441

4. Haemolytic uraemic syndromes in the British Isles, 1985-8: association with verocytotoxin producing Escherichia coli. Part 2: Microbiological aspects.

Authors: H Kleanthous; H R Smith; S M Scotland; R J Gross; B Rowe; C M Taylor; D V Milford
Journal: Arch Dis Child Date: 1990-07 Impact factor: 3.791

5. Bcl-2 antiapoptotic protein mediates verotoxin II-induced cell death: possible association between bcl-2 and tissue failure by E. coli O157:H7.

Authors: A Suzuki; H Doi; F Matsuzawa; S Aikawa; K Takiguchi; H Kawano; M Hayashida; S Ohno
Journal: Genes Dev Date: 2000-07-15 Impact factor: 11.361

6. Serum amyloid P component is the Shiga toxin 2-neutralizing factor in human blood.

Authors: T Kimura; S Tani; Y Matsumoto Yi; T Takeda
Journal: J Biol Chem Date: 2001-08-31 Impact factor: 5.157

7. Cloned Shiga toxin 2 B subunit induces apoptosis in Ramos Burkitt's lymphoma B cells.

Authors: Paola Marcato; George Mulvey; Glen D Armstrong
Journal: Infect Immun Date: 2002-03 Impact factor: 3.441

8. Assessment in mice of the therapeutic potential of tailored, multivalent Shiga toxin carbohydrate ligands.

Authors: George L Mulvey; Paola Marcato; Pavel I Kitov; Joanna Sadowska; David R Bundle; Glen D Armstrong
Journal: J Infect Dis Date: 2003-02-07 Impact factor: 5.226

9. Differential tissue targeting and pathogenesis of verotoxins 1 and 2 in the mouse animal model.

Authors: Niels W P Rutjes; Beth A Binnington; Charles R Smith; Mark D Maloney; Clifford A Lingwood
Journal: Kidney Int Date: 2002-09 Impact factor: 10.612

10. Toxin genotypes and plasmid profiles as determinants of systemic sequelae in Escherichia coli O157:H7 infections.

Authors: S M Ostroff; P I Tarr; M A Neill; J H Lewis; N Hargrett-Bean; J M Kobayashi
Journal: J Infect Dis Date: 1989-12 Impact factor: 5.226

15 in total

1. In vivo supramolecular templating enhances the activity of multivalent ligands: a potential therapeutic against the Escherichia coli O157 AB5 toxins.

Authors: Pavel I Kitov; George L Mulvey; Thomas P Griener; Tomasz Lipinski; Dmitry Solomon; Eugenia Paszkiewicz; Jared M Jacobson; Joanna M Sadowska; Missao Suzuki; Ken-Ichi Yamamura; Glen D Armstrong; David R Bundle
Journal: Proc Natl Acad Sci U S A Date: 2008-10-27 Impact factor: 11.205

2. Binding of Pk-trisaccharide analogs of globotriaosylceramide to Shiga toxin variants.

Authors: Hailemichael O Yosief; Suri S Iyer; Alison A Weiss
Journal: Infect Immun Date: 2013-05-20 Impact factor: 3.441

Review 3. The interactions of human neutrophils with shiga toxins and related plant toxins: danger or safety?

Authors: Maurizio Brigotti
Journal: Toxins (Basel) Date: 2012-03-01 Impact factor: 4.546

4. Molecular basis of differential B-pentamer stability of Shiga toxins 1 and 2.

Authors: Deborah G Conrady; Michael J Flagler; David R Friedmann; Bradley D Vander Wielen; Rhett A Kovall; Alison A Weiss; Andrew B Herr
Journal: PLoS One Date: 2010-12-28 Impact factor: 3.240

5. Lipopolysaccharide renders transgenic mice expressing human serum amyloid P component sensitive to Shiga toxin 2.

Authors: Thomas P Griener; Jonathan G Strecker; Romney M Humphries; George L Mulvey; Carmen Fuentealba; Robert E W Hancock; Glen D Armstrong
Journal: PLoS One Date: 2011-06-24 Impact factor: 3.240

6. Comparisons of native Shiga toxins (Stxs) type 1 and 2 with chimeric toxins indicate that the source of the binding subunit dictates degree of toxicity.

Authors: Lisa M Russo; Angela R Melton-Celsa; Michael J Smith; Alison D O'Brien
Journal: PLoS One Date: 2014-03-26 Impact factor: 3.240