OBJECTIVE: To investigate the effects of heart rate on the Doppler measurements of left ventricular function and to determine the normal pattern of rate dependency. SETTING: University hospital specialising in internal medicine. PARTICIPANTS: 14 healthy male volunteers 10 of whom were studied. INTERVENTION: Transoesophageal atrial pacing. MAIN OUTCOME MEASURES: At paced rates of 70, 80, and 90 ppm the ratio of early to late peak transmitral flow velocity (E/A) was 1.97 (0.28), 1.49 (0.21), and 0.95 (0.11) respectively; the ratio of early to late time-velocity integrals of transmitral flow (Ei/Ai) was 3.03 (0.51), 2.11 (0.24), and 1.14 (0.30) respectively; and the atrial filling fraction (AFF) was 0.17 (0.03), 0.21, (0.04), and 0.24 (0.04) (mean (SD)). RESULTS: Heart rate showed a linear correlation with E/A (r2 = 0.806), Ei/Ai (r2 = 0.838), and AFF (r2 = 0.343). Neither the peak aortic flow velocity or the mean aortic flow acceleration showed significant changes during pacing at rates of 70, 80, 90, and 100 ppm. CONCLUSIONS: E/A and Ei/Ai can be expected to decrease by 0.5 and 0.9 for each increase of 10 beats/min in heart rate. Knowledge of this relation may be useful for the development of algorithms to correct for heart rate when diastolic function is assessed.
OBJECTIVE: To investigate the effects of heart rate on the Doppler measurements of left ventricular function and to determine the normal pattern of rate dependency. SETTING: University hospital specialising in internal medicine. PARTICIPANTS: 14 healthy male volunteers 10 of whom were studied. INTERVENTION: Transoesophageal atrial pacing. MAIN OUTCOME MEASURES: At paced rates of 70, 80, and 90 ppm the ratio of early to late peak transmitral flow velocity (E/A) was 1.97 (0.28), 1.49 (0.21), and 0.95 (0.11) respectively; the ratio of early to late time-velocity integrals of transmitral flow (Ei/Ai) was 3.03 (0.51), 2.11 (0.24), and 1.14 (0.30) respectively; and the atrial filling fraction (AFF) was 0.17 (0.03), 0.21, (0.04), and 0.24 (0.04) (mean (SD)). RESULTS: Heart rate showed a linear correlation with E/A (r2 = 0.806), Ei/Ai (r2 = 0.838), and AFF (r2 = 0.343). Neither the peak aortic flow velocity or the mean aortic flow acceleration showed significant changes during pacing at rates of 70, 80, 90, and 100 ppm. CONCLUSIONS: E/A and Ei/Ai can be expected to decrease by 0.5 and 0.9 for each increase of 10 beats/min in heart rate. Knowledge of this relation may be useful for the development of algorithms to correct for heart rate when diastolic function is assessed.
Authors: I Van Dam; J Fast; T de Boo; J Hopman; A Van Oort; A Heringa; J Alsters; T Van Der Werf; O Daniëls Journal: Eur Heart J Date: 1988-02 Impact factor: 29.983
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Authors: William H Hoffman; Gregory G Passmore; David W Hannon; Monica V Talor; Pam Fox; Catherine Brailer; Dynita Haislip; Cynthia Keel; Glenn Harris; Noel R Rose; Irma Fiordalisi; Daniela Čiháková Journal: PLoS One Date: 2013-08-27 Impact factor: 3.240
Authors: Toshihiro Ogawa; Lawrence N Scotten; David K Walker; Ajit P Yoganathan; Renee L Bess; Cheryl K Nordstrom; Julius M Gardin Journal: Cardiovasc Ultrasound Date: 2005-09-01 Impact factor: 2.062