Literature DB >> 1449528

Inhibition of adenosine deaminase by azapurine ribonucleosides.

D S Shewach1, S H Krawczyk, O L Acevedo, L B Townsend.   

Abstract

We have synthesized several 8-azapurine nucleosides as inhibitors of adenosine deaminase. The presence of a nitrogen on the imidazole ring decreased the Ki value for nebularine by 100-fold but did not lower the Ki value for coformycin. Evaluation of these compounds in a MOLT-4 growth assay revealed that 2-azacoformycin was as effective as 2'-deoxycoformycin in potentiating growth inhibition by 2'-deoxyadenosine. The azapurine nucleosides merit further study as antitumor agents.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1449528     DOI： 10.1016/0006-2952(92)90061-m

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  4 in total

1.  A transition state analogue for an RNA-editing reaction.

Authors:  Brittany L Haudenschild; Olena Maydanovych; Eduardo A Véliz; Mark R Macbeth; Brenda L Bass; Peter A Beal
Journal:  J Am Chem Soc       Date:  2004-09-15       Impact factor: 15.419

2.  Contrasting behavior of conformationally locked carbocyclic nucleosides of adenosine and cytidine as substrates for deaminases.

Authors:  Victor E Marquez; Gottfried K Schroeder; Olaf R Ludek; Maqbool A Siddiqui; Abdallah Ezzitouni; Richard Wolfenden
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2009-05       Impact factor: 1.381

3.  The loss of a hydrogen bond: Thermodynamic contributions of a non-standard nucleotide.

Authors:  Elizabeth A Jolley; Brent M Znosko
Journal:  Nucleic Acids Res       Date:  2017-02-17       Impact factor: 16.971

4.  Spectroscopic investigations and hydrogen bond interactions of 8-aza analogues of xanthine, theophylline and caffeine: a theoretical study.

Authors:  Mylsamy Karthika; Ramasamy Kanakaraju; Lakshmipathi Senthilkumar
Journal:  J Mol Model       Date:  2013-01-15       Impact factor: 1.810
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.