Literature DB >> 1449508

Stimulation of serum-free cell proliferation by coenzyme Q.

I L Sun1, E E Sun, F L Crane.   

Abstract

Coenzyme Q added to culture media stimulates the growth of HeLa and Balb/3T3 cells in serum free conditions. The stimulation by coenzyme Q is additive to the stimulation by ferricyanide, an impermeable electron acceptor for the transplasma membrane electron transport. alpha Tocopherylquinone can also stimulate cell growth, but vitamin K1 is inactive or inhibitory. The response to coenzyme Q and ferricyanide is enhanced with insulin. A contribution to plasma membrane NADH oxidation or modification of the membrane quinone redox balance can be a basis for the growth stimulation.

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Year:  1992        PMID： 1449508     DOI： 10.1016/0006-291x(92)91517-t

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

1.  Effectors of the mammalian plasma membrane NADH-oxidoreductase system. Short-chain ubiquinone analogues as potent stimulators.

Authors:  F Vaillant; J A Larm; G L McMullen; E J Wolvetang; A Lawen
Journal:  J Bioenerg Biomembr       Date:  1996-12       Impact factor: 2.945

2.  Extracellular ascorbate stabilization as a result of transplasma electron transfer in Saccharomyces cerevisiae.

Authors:  C Santos-Ocaña; P Navas; F L Crane; F Córdoba
Journal:  J Bioenerg Biomembr       Date:  1995-12       Impact factor: 2.945

3.  Enhancement of antibody production by the addition of Coenzyme-Q(10).

Authors:  Yoshinobu Konno; Motoi Aoki; Masakazu Takagishi; Naoto Sakai; Masamichi Koike; Kaori Wakamatsu; Shinji Hosoi
Journal:  Cytotechnology       Date:  2011-01-01       Impact factor: 2.058

4.  Iron reverses impermeable chelator inhibition of DNA synthesis in CCl 39 cells.

Authors:  F J Alcain; H Löw; F L Crane
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-16       Impact factor: 11.205
  4 in total

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