Literature DB >> 144916

Oligomycin-dependent ionophoric protein subunit of mitochondrial adenosinetriphosphatase.

R S Criddle, L Packer, P Shieh.   

Abstract

A proteolipid isolated from yeast mitochondrial adenosinetriphosphatase (subunit 9) (ATP phosphohydrolase; EC 3.6.1.3) by chloroform/methanol extraction has been shown to discharge photo-induced potentials across a planar phospholipid membrane containing bacteriorhodopsin. Oligomycin, a specific inhibitor of oxidative phosphorylation which binds to this protein, allows the potential gradient to be reestablished. When proteolipid was isolated from an oligomycin-resistant strain, ionophoric activity was still obtained but the effect was not reversed by oligomycin. These studies suggest that the hydrophobic subunit-9 polypeptide is the ionophoric component linking ATP synthesis (hydrolysis) with proton translocation.

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Year:  1977        PMID： 144916      PMCID： PMC431929          DOI： 10.1073/pnas.74.10.4306

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  A coupling factor from sarcoplasmic reticulum required for the translocation of Ca2+ ions in a reconstituted Ca2+ATPase pump.

Authors:  E Racker; E Eytan
Journal:  J Biol Chem       Date:  1975-09-25       Impact factor: 5.157

2.  Isolation of a chloroplast N,N'-dicyclohexylcarbodiimide-binding proteolipid, active in proton translocation.

Authors:  N Nelson; E Eytan; B E Notsani; H Sigrist; K Sigrist-Nelson; C Gitler
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

3.  Antibiotics as tools for metabolic studies. I. A survey of toxic antibiotics in respiratory, phosphorylative and glycolytic systems.

Authors:  H A LARDY; D JOHNSON; W C McMURRAY
Journal:  Arch Biochem Biophys       Date:  1958-12       Impact factor: 4.013

4.  Affinity labeling of yeast mitochondrial adenosine triphosphatase by reduction with [3H]borohydride.

Authors:  R K Enns; R S Criddle
Journal:  Arch Biochem Biophys       Date:  1977-08       Impact factor: 4.013

5.  Assembly of the mitochondrial membrane system XVI. Modified form of the ATPase proteolipid in oligomycin-resistant mutants of Saccharomyces cerevisiae.

Authors:  A Tzagoloff; A Akai; F Foury
Journal:  FEBS Lett       Date:  1976-06-15       Impact factor: 4.124

6.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

7.  Proton translocation by ATPase and bacteriorhodopsin.

Authors:  Y Kagawa; K Ohno; M Yoshida; Y Takeuchi; N Sone
Journal:  Fed Proc       Date:  1977-05

8.  Separate effects of mercurial compounds on the ionophoric and hydrolytic functions of the (Ca++ +Mg++)-ATPase of sarcoplasmic reticulum.

Authors:  A E Shamoo; D H MacLennan
Journal:  J Membr Biol       Date:  1975-12-04       Impact factor: 1.843

9.  Identification of the dicyclohexylcarbodiimide-reactive protein component of the adenosine 5'-triphosphate energy-transducing system of Escherichia coli.

Authors:  R H Fillingame
Journal:  J Bacteriol       Date:  1975-11       Impact factor: 3.490

10.  Localization of ionophore activity in a 20,000-dalton fragment of the adenosine triphosphatase of Sarcoplasmic reticulum.

Authors:  A E Shamoo; T E Ryan; P S Stewart; D H MacLennan
Journal:  J Biol Chem       Date:  1976-07-10       Impact factor: 5.157
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  16 in total

1.  Measuring interference of drug-like molecules with the respiratory chain: toward the early identification of mitochondrial uncouplers in lead finding.

Authors:  Ursula Stock; Hans Matter; Kerstin Diekert; Wolfgang Dörner; Stefan Dröse; Thomas Licher
Journal:  Assay Drug Dev Technol       Date:  2013-08-30       Impact factor: 1.738

Review 2.  Bacterial adenosine 5'-triphosphate synthase (F1F0): purification and reconstitution of F0 complexes and biochemical and functional characterization of their subunits.

Authors:  E Schneider; K Altendorf
Journal:  Microbiol Rev       Date:  1987-12

Review 3.  Structure and function of proton-translocating adenosine triphosphatase (F0F1): biochemical and molecular biological approaches.

Authors:  M Futai; H Kanazawa
Journal:  Microbiol Rev       Date:  1983-09

Review 4.  Structure and function of the membrane-integral components of the mitochondrial H+-ATPase.

Authors:  J Houstĕk; J Kopecký; P Svoboda; Z Drahota
Journal:  J Bioenerg Biomembr       Date:  1982-02       Impact factor: 2.945

5.  The dicyclohexylcarbodiimide-binding protein c of ATP synthase from Escherichia coli is not sufficient to express an efficient H+ conduction.

Authors:  P Friedl; G Bienhaus; J Hoppe; H U Schairer
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

6.  Protein interactions with lipid bilayers: the channels of kidney plasma membrane proteolipids.

Authors:  M T Tosteson; V S Sapirstein
Journal:  J Membr Biol       Date:  1981       Impact factor: 1.843

7.  Isolation, characterization, and reconstitution of a solubilized fraction containing the hydrophobic sector of the mitochondrial proton pump.

Authors:  M Alfonzo; M A Kandrach; E Racker
Journal:  J Bioenerg Biomembr       Date:  1981-12       Impact factor: 2.945

8.  Effect of chemical modifiers of amino acid residues on proton conduction by the H+-ATPase of mitochondria.

Authors:  F Guerrieri; S Papa
Journal:  J Bioenerg Biomembr       Date:  1981-12       Impact factor: 2.945

9.  Oligomycin toxicity in intact rats.

Authors:  R Kramar; M Hohenegger; A N Srour; G Khanakah
Journal:  Agents Actions       Date:  1984-12

10.  Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase.

Authors:  D R Sanadi; M Pringle; L Kantham; J B Hughes; A Srivastava
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205
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