Literature DB >> 14486841

A comparison of a series of newer anticholinergic agents with atropine as regards their effect on saliva flow and gastric secretion in man.

D W PIPER, M C STIEL.   

Abstract

The effect of anticholinergic agents-atropine, propantheline, oxyphencyclimine, and propionyl atropine methyl nitrate-on silva flow and on hypoglycaemic stimulated gastric secretion has been studied. The acid secretion of the nervous phase of gastric secretion was inhibited by anticholinergic drugs. They influenced gastric secretion to a greater extent than saliva flow. Both propantheline and oxyphencyclimine have a selective action on the stomach superior to atropine. Propionyl atropine methyl nitrate appears to have only weak anticholinergic activity in the dose recommended and is not superior to atropine.

Entities:  

Keywords:  ATROPINE/pharmacology; SALIVARY GLANDS/pharmacology; STOMACH/pharmacology

Mesh：

Substances：

Year:  1962        PMID： 14486841      PMCID： PMC1413305          DOI： 10.1136/gut.3.1.65

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  18 in total

1.  Anticholinergic drugs; survey of the literature and some experimental observations.

Authors:  W H BACHRACH
Journal:  Am J Dig Dis       Date:  1958-10

2.  The effect of a new anticholinergic agent, oxyphencylimine hydrochloride, on gastric secretion.

Authors:  D W PIPER; F M ELLIOTT; A S SIETSMA; A W PRYOR
Journal:  Med J Aust       Date:  1960-02-13       Impact factor: 7.738

3.  Optimal effective dose of anticholinergic drug in peptic ulcer therapy.

Authors:  D C SUN; H SHAY
Journal:  AMA Arch Intern Med       Date:  1956-04

4.  Effects of tricyclamol on gastric secretion and gastrointestinal motility in peptic ulcer; experimental studies and clinical observations.

Authors:  A P BOLEMAN; A M KASICH; J C RAFSKY
Journal:  Am J Dig Dis       Date:  1956-09

5.  The physiology of the gastric antrum; experimental studies on isolated antrum pouches in dogs.

Authors:  E R WOODWARD; E S LYON; J LANDOR; L R DRAGSTEDT
Journal:  Gastroenterology       Date:  1954-12       Impact factor: 22.682

6.  Experimental effect of two recent anticholinergic drugs on insulin-induced gastric secretion in duodenal ulcer.

Authors:  B B WEISIGER; J O BURKE; K PLUMMER
Journal:  Gastroenterology       Date:  1954-10       Impact factor: 22.682

7.  Effect of new quaternary ammonium compound on gastric secretion and gastrointestinal motility.

Authors:  R A ROBACK; J M BEAL
Journal:  Gastroenterology       Date:  1953-09       Impact factor: 22.682

8.  The effect of newer anticholinergic drugs upon gastric secretion in man.

Authors:  J B KIRSNER; E LEVIN; W L PALMER
Journal:  Gastroenterology       Date:  1953-02       Impact factor: 22.682

9.  Banthine for peptic ulcer: clinical and physiologic considerations; a preliminary report.

Authors:  A WINKELSTEIN
Journal:  Gastroenterology       Date:  1952-03       Impact factor: 22.682

10.  The effect of banthine on gastric secretion in man.

Authors:  E LEVIN; J B KIRSNER; W L PALMER
Journal:  Gastroenterology       Date:  1952-07       Impact factor: 22.682
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  8 in total

1.  RATIONALE FOR THE USE OF ANTICHOLINERGIC AGENTS IN THE MANAGEMENT OF DUODENAL ULCER.

Authors:  K H SOERGEL; W J HOGAN
Journal:  Am J Dig Dis       Date:  1964-09

Review 2.  Medical management of peptic ulcer with reference to anti-ulcer agents in other gastro-intestinal diseases.

Authors:  D W Piper; T R Heap
Journal:  Drugs       Date:  1972       Impact factor: 9.546

3.  Clinical evaluation of three long-acting anticholinergic compounds.

Authors:  M D Kaye; J Rhodes; P M Sweetnam
Journal:  Gut       Date:  1968-10       Impact factor: 23.059

Review 4.  Drugs for the prevention of peptic ulcer recurrence.

Authors:  D W Piper
Journal:  Drugs       Date:  1983-11       Impact factor: 9.546

5.  The relative effect of an anticholinergic drug, glycopyrrolate, on basal gastric secretion and sweat- and salivary-gland activity.

Authors:  K Juniper
Journal:  Am J Dig Dis       Date:  1967-05

6.  Nonparallel gastric and salivary gland inhibition produced by anticholinergic drugs in sham-fed dogs.

Authors:  R H Kubin; W R Keeler; A P Klotz
Journal:  Am J Dig Dis       Date:  1967-04

7.  Measurement of gastric secretion and acidity.

Authors:  J E Lennard-Jones
Journal:  Proc R Soc Med       Date:  1966

8.  [Comparative study on the effect of anticholinergic substances on basic gastric secretion as well as on gastric secretion stimulated by pentagastrin or hypoglycemia (author's transl)].

Authors:  K Kutz; G Schuler; U Brenner; S E Miederer
Journal:  Klin Wochenschr       Date:  1976-05-15
  8 in total

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