Literature DB >> 1448617

DOT-ELISA for detection of phenolic glycolipid PGL-Tb1 and diacyl-trehalose antigens of Mycobacterium tuberculosis.

F Papa1, M Luquin, H L David.   

Abstract

A DOT-ELISA method for detection of 2,3-diacyl-trehalose (DAT, previously referred to as SL-IV antigen) and triglycosyl phenol phthiocerol di-mycocerosate (PGL-Tb1) antigens from Mycobacterium tuberculosis is described. The method enabled the detection of both antigens in 14 clinical isolates of M. tuberculosis from different geographic origins; the presence of the glycolipids was confirmed by chemical analysis. It was therefore concluded that the synthesis of both of these compounds is characteristic of the species.

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Year:  1992        PMID： 1448617     DOI： 10.1016/0923-2508(92)90024-i

Source DB:  PubMed          Journal:  Res Microbiol        ISSN： 0923-2508            Impact factor:   3.992


  4 in total

1.  Monoclonal antibodies to surface antigens of Mycobacterium tuberculosis and their use in a modified enzyme-linked immunosorbent spot assay for detection of mycobacteria.

Authors:  A Glatman-Freedman; J M Martin; P F Riska; B R Bloom; A Casadevall
Journal:  J Clin Microbiol       Date:  1996-11       Impact factor: 5.948

2.  Production of monoclonal antibody to a phenolic glycolipid of Mycobacterium tuberculosis and its use in detection of the antigen in clinical isolates.

Authors:  S N Cho; J S Shin; M Daffe; Y Chong; S K Kim; J D Kim
Journal:  J Clin Microbiol       Date:  1992-12       Impact factor: 5.948

Review 3.  Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis.

Authors:  Mira Holzheimer; Jeffrey Buter; Adriaan J Minnaard
Journal:  Chem Rev       Date:  2021-06-30       Impact factor: 60.622

4.  Asymmetric Total Synthesis of Mycobacterial Diacyl Trehaloses Demonstrates a Role for Lipid Structure in Immunogenicity.

Authors:  Mira Holzheimer; Josephine F Reijneveld; Alexandrea K Ramnarine; Georgios Misiakos; David C Young; Eri Ishikawa; Tan-Yun Cheng; Sho Yamasaki; D Branch Moody; Ildiko Van Rhijn; Adriaan J Minnaard
Journal:  ACS Chem Biol       Date:  2020-04-24       Impact factor: 5.100
  4 in total

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