Literature DB >> 1448426

Molecular weight changes in polymer erosion.

A D'Emanuele1, J Hill, J A Tamada, A J Domb, R Langer.   

Abstract

We report a study of the effects of polymer molecular weight on the erosion of polyanhydride copolymer matrices composed of 1,3-bis(p-carboxyphenoxy)-propane (CPP) and sebacic acid (SA) in aqueous solution. The erosion profile characteristically displays an induction period during which the erosion rate is relatively slow. The length of this period depends on the initial molecular weight of the polymer. The induction period may be characterized as a time during which a rapid decrease in polymer molecular weight occurs, the end of this period correlating with the time required for the polymer molecular weight to decrease to below a value of approximately 5000 (MW).

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Year:  1992        PMID： 1448426     DOI： 10.1023/a:1015801216466

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  8 in total

1.  Poly(lactic/glycolic acid) biodegradable drug-polymer matrix systems.

Authors:  J P Kitchell; D L Wise
Journal:  Methods Enzymol       Date:  1985       Impact factor: 1.600

2.  Bioerodible polyanhydrides for controlled drug delivery.

Authors:  H B Rosen; J Chang; G E Wnek; R J Linhardt; R Langer
Journal:  Biomaterials       Date:  1983-04       Impact factor: 12.479

3.  Degradation of poly(ester) microspheres.

Authors:  H T Wang; H Palmer; R J Linhardt; D R Flanagan; E Schmitt
Journal:  Biomaterials       Date:  1990-11       Impact factor: 12.479

4.  Polymers for biodegradable medical devices. VII. Hydroxybutyrate-hydroxyvalerate copolymers: degradation of copolymers and their blends with polysaccharides under in vitro physiological conditions.

Authors:  S J Holland; M Yasin; B J Tighe
Journal:  Biomaterials       Date:  1990-04       Impact factor: 12.479

5.  Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity.

Authors:  K W Leong; P D D'Amore; M Marletta; R Langer
Journal:  J Biomed Mater Res       Date:  1986-01

6.  Polymers for biodegradable medical devices. II. Hydroxybutyrate-hydroxyvalerate copolymers: hydrolytic degradation studies.

Authors:  S J Holland; A M Jolly; M Yasin; B J Tighe
Journal:  Biomaterials       Date:  1987-07       Impact factor: 12.479

7.  Polyanhydrides for controlled release of bioactive agents.

Authors:  K W Leong; J Kost; E Mathiowitz; R Langer
Journal:  Biomaterials       Date:  1986-09       Impact factor: 12.479

8.  Bioerodible polyanhydrides as drug-carrier matrices. I: Characterization, degradation, and release characteristics.

Authors:  K W Leong; B C Brott; R Langer
Journal:  J Biomed Mater Res       Date:  1985-10
  8 in total
  4 in total

1.  Preparation and characterization of carmustine loaded polyanhydride wafers for treating brain tumors.

Authors:  A J Domb; Z H Israel; O Elmalak; D Teomim; A Bentolila
Journal:  Pharm Res       Date:  1999-05       Impact factor: 4.200

2.  In Vitro Degradation of an Aromatic Polyanhydride with Enhanced Thermal Properties.

Authors:  Sabrina S Snyder; Theodore J Anastasiou; Kathryn E Uhrich
Journal:  Polym Degrad Stab       Date:  2015-05-01       Impact factor: 5.030

3.  Erosion kinetics of hydrolytically degradable polymers.

Authors:  J A Tamada; R Langer
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

4.  Preparation and characterization of protein-loaded polyanhydride microspheres.

Authors:  Lin Sun; Shaobing Zhou; Weijia Wang; Qiuxiang Su; Xiaohong Li; Jie Weng
Journal:  J Mater Sci Mater Med       Date:  2009-05-08       Impact factor: 3.896
  4 in total

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