Lack of involvement of monoamine oxidase inhibition in the lethality of acute poisoning by chlordimeform.

Depletion of serotonin or norepinephrine in male rats by pretreatment with p-chlorophenylalanine or DL-alpha-methyl-p-tyrosine, respectively, failed to reduce the lethality of the monoamine oxidase-inhibiting acaricide, chlordimeform. Administration of phenylephrine, a directly acting alpha-adrenergic agonist, with chlordimeform did not increase the lethality of chlordimeform. Thus, monoamine oxidase inhibition by chlordimeform does not seem to contribute to its lethality.