Literature DB >> 144698

Meiosis I non-disjunction as the main cause of trisomy 21.

J A Robinson.   

Abstract

The relative roles of Meiosis I and Meiosis II non-disjunctions in the causation of trisomy 21 have been assessed by analysing the distribution of polymorphic phenotypes of the chromosomes 21 in a group of individuals with Down's syndrome. The data suggest that the majority of cases of trisomy 21 are due to meiosis I non-disjunctions.

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Year:  1977        PMID： 144698     DOI： 10.1007/bf00273150

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  4 in total

1.  A fluorescence polymorphism associated with Down's syndrome?

Authors:  J A Robinson; M Newton
Journal:  J Med Genet       Date:  1977-02       Impact factor: 6.318

2.  On the origin of the supernumerary chromosome in autosomal trisomies--with special reference to Down's syndrome. A bias in tracing nondisjunction by chromosomal and biochemical polymorphisms.

Authors:  U Langenbeck; I Hansmann; B Hinney; V Hönig
Journal:  Hum Genet       Date:  1976-07-27       Impact factor: 4.132

3.  Origin of extra chromosome in trisomy 21.

Authors:  J A Robinson
Journal:  Lancet       Date:  1973-01-20       Impact factor: 79.321

4.  Leukocytes cultured from small inocula of whole blood and the preparation of metaphase chromosomes by treatment with hypotonic KCl.

Authors:  D A Hungerford
Journal:  Stain Technol       Date:  1965-11
  4 in total

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