| Literature DB >> 1446923 |
I Sominskaya1, V Bichko, P Pushko, A Dreimane, D Snikere, P Pumpens.
Abstract
A hepatitis B virus preS2 deletion library with the preS2 sequence fused to the coat protein of the RNA phage fr (fr CP) as a carrier has been constructed and used for the approximate localization of epitope recognized by a panel of murine monoclonal anti-preS2 antibodies. DNA copies of putative preS2 epitopes were synthesized and cloned within the fr CP gene. Tetrapeptide Gln-Asp-Pro-Arg (QDPR) corresponding to the preS (132-135) sequence was found to be the minimal sufficient recognition site for one of the monoclonal antibodies, S26. The closely related tetrapeptide EDPR did not mimic the epitope activity of QDPR.Entities:
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Year: 1992 PMID： 1446923 DOI： 10.1016/0165-2478(92)90043-n
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685