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Literature DB >> 14468899

Effect of reserpine on the acetylcholine content of the heart, the ileum and the hypothalamus of the dog.

Abstract

The effect of intravenous administration of reserpine in 10 dogs was studied on the acetylcholine content of the sino-atrial node, the right auricle and the right ventricle of the heart, the ileum and the hypothalamus of dog. The general sedation, the bradycardia, and the purgative effects of reserpine were also noted. Tissues were removed for estimation of acetylcholine when bradycardia was maximal. Reserpine increased the acetylcholine content of all the tissues studied. The increase in the peripheral tissues was greater than in the hypothalamus. The bradycardia and the purgative effects of reserpine may be related to the increase of the acetylcholine content of the sino-atrial node and the ileum.

Entities: Chemical Disease Species

Keywords: ACETYLCHOLINE/metabolism; HYPOTHALAMUS/metabolism; ILEUM/metabolism; MYOCARDIUM/metabolism; RESERPINE/pharmacology

Mesh：

Substances：
Reserpine
Acetylcholine

Year: 1962 PMID： 14468899 PMCID： PMC1482159 DOI： 10.1111/j.1476-5381.1962.tb01163.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

11 in total

3. THE EFFECT OF RESERPINE ON THE ACETYLCHOLINE CONCENTRATION IN HYPOTHALAMUS, ILEUM, AND HEART OF THE DOG AFTER BILATERA VAGOTOMY AND GANGLIONIC BLOCKADE.

Authors: C L MALHOTRA; P G PUNDLIK
Journal: Br J Pharmacol Chemother Date: 1965-02

4. The effect of reserpine on the acetylcholine release of the cerebral cortex of dog under different anaesthetics.

Authors: C L Malhotra; V L Mehta
Journal: Br J Pharmacol Chemother Date: 1966-05

5. OBSERVATIONS ON THE SIGNIFICANCE OF 5-HYDROXYTRYPTAMINE IN RELATION TO THE PERISTALTIC REFLEX OF THE RAT.

Authors: D J BOULLIN
Journal: Br J Pharmacol Chemother Date: 1964-08

6. THE EFFECT OF INTRA(CEREBRO)VENTRICULAR RESERPINE ON THE ACETYLCHOLINE CONTENT OF THE HEART, ILEUM AND HYPOTHALAMUS OF THE DOG.

Authors: C L MALHOTRA; K PRASAD
Journal: Br J Pharmacol Chemother Date: 1963-10

6 in total

Effect of reserpine on the acetylcholine content of the heart, the ileum and the hypothalamus of the dog.

1. Drug therapy in hypertension; a critical review.

2. Evidence that serotonin has a role in brain function.

3. [Reserpine and the motility of the intestinal villi].

4. The release of norepinephrine from the mammalian heart by reserpine.

5. Depression by reserpine of the noradrenaline concentration in the hypothalamus of the cat.

6. Release of blood platelet serotonin by reserpine and lack of effect on bleeding time.

7. Rauwolfia serpentina in the treatment of high blood-pressure.

8. Serotonin as a mediator of reserpine action in brain.

9. Influence of temperature on vagal inhibition and liberation of acetylcholine in frog hearts.

10. Effects of reserpine on blood-pressure responses evoked from the hypothalamus.

1. THE INFLUENCE OF HEMICHOLINIUM NO. 3 AND VAGUS STIMULATION ON ACETYLCHOLINE DISTRIBUTION IN THE CAT'S HEART.

2. THE INFLUENCE OF ACUTE SYMPATHETIC DENERVATION, RESERPINE AND CHOLINE XYLYL ETHER ON VAGAL ESCAPE.

3. THE EFFECT OF RESERPINE ON THE ACETYLCHOLINE CONCENTRATION IN HYPOTHALAMUS, ILEUM, AND HEART OF THE DOG AFTER BILATERA VAGOTOMY AND GANGLIONIC BLOCKADE.

4. The effect of reserpine on the acetylcholine release of the cerebral cortex of dog under different anaesthetics.

5. OBSERVATIONS ON THE SIGNIFICANCE OF 5-HYDROXYTRYPTAMINE IN RELATION TO THE PERISTALTIC REFLEX OF THE RAT.

6. THE EFFECT OF INTRA(CEREBRO)VENTRICULAR RESERPINE ON THE ACETYLCHOLINE CONTENT OF THE HEART, ILEUM AND HYPOTHALAMUS OF THE DOG.