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Literature DB >> 14463528

Reticuloendothelial clearance of circulating fibrin in the pathogenesis of the generalized Shwartzman reaction.

Abstract

Intravenous injections of endotoxin or infusions of thrombin in the rabbit initiate intravascular coagulation but do not usually result in massive deposition of fibrin. It has been proposed that the reticuloendothelial system may function efficiently in the removal of circulating fibrin; its blockade permits reproduction of all of the features of the generalized Shwartzman reaction by infusions of thrombin. In the rabbit the reticuloendothelial system may constitute the major protective mechanism against the vasculo-occlusive lesions of the generalized Shwartzman reaction, which appears to be the direct consequence of intravascular fibrin formation and deposition.

Entities: Disease Gene Species

Keywords: ALLERGY/experimental; ANTICOAGULANTS/pharmacology; FIBRIN/metabolism; KIDNEY/blood supply; RETICULOENDOTHELIAL SYSTEM/physiology

Mesh：

Substances：

Year: 1962 PMID： 14463528 PMCID： PMC2137542 DOI： 10.1084/jem.115.5.1065

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

27 in total

1. Effect of bacterial endotoxins on the reticuloendothelial system.

Authors: B BENACERRAF; M M SEBESTYEN
Journal: Fed Proc Date: 1957-09

2. Formation and properties of the activator of plasminogen and of human and bovine plasmin.

Authors: S MULLERTZ
Journal: Biochem J Date: 1955-11 Impact factor: 3.857

3. [Phagocytosis of a fraction of heated and iodated serum by the reticuloendothelial system and subsequent behavior of its cells toward other colloids].

Authors: B BENACERRAF; B N HALPERN; C STIFFEL; S CRUCHAUD; G BIOZZI
Journal: Ann Inst Pasteur (Paris) Date: 1955-12

4. Cold-precipitation by heparin of a protein in rabbit and human plasma.

Authors: L THOMAS; R T SMITH; R VON KORFF
Journal: Proc Soc Exp Biol Med Date: 1954 Aug-Sep

5. Effect of carboxylic and amino acids on fibrinolysis produced by plasmin, plasminogen activator and proteases.

Authors: S MULLERTZ
Journal: Proc Soc Exp Biol Med Date: 1954-02

6. Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity.

Authors: G BIOZZI; B BENACERRAF; B N HALPERN
Journal: Br J Exp Pathol Date: 1953-08

7. The fibrin plate method for estimating fibrinolytic activity.

Authors: T ASTRUP; S MULLERTZ
Journal: Arch Biochem Biophys Date: 1952-10 Impact factor: 4.013

8. Studies on the generalized Shwartzman reaction. IV. Prevention of the local and generalized Shwartzman reactions with heparin.

Authors: R A GOOD; L THOMAS
Journal: J Exp Med Date: 1953-06 Impact factor: 14.307

9. Studies on the generalized Shwartzman reaction. II. The production of bilateral cortical necrosis of the kidneys by a single injection of bacterial toxin in rabbits previously treated with thorotrast or trypan blue.

Authors: R A GOOD; L THOMAS
Journal: J Exp Med Date: 1952-12 Impact factor: 14.307

10. Studies on the generalized Shwartzman reaction: I. General observations concerning the phenomenon.

Authors: L THOMAS; R A GOOD
Journal: J Exp Med Date: 1952-12 Impact factor: 14.307

29 in total

1. STUDIES ON THE PATHOGENESIS OF ACUTE INFLAMMATION. V. AN ASSESSMENT OF FACTORS THAT INFLUENCE IN VITRO THE PHAGOCYTIC AND ADHESIVE PROPERTIES OF LEUKOCYTES OBTAINED FROM RABBIT PERITONEAL EXUDATE.

Authors: F ALLISON; M G LANCASTER; J L CROSTHWAITE
Journal: Am J Pathol Date: 1963-11 Impact factor: 4.307

Reticuloendothelial clearance of circulating fibrin in the pathogenesis of the generalized Shwartzman reaction.

1. Effect of bacterial endotoxins on the reticuloendothelial system.

2. Formation and properties of the activator of plasminogen and of human and bovine plasmin.

3. [Phagocytosis of a fraction of heated and iodated serum by the reticuloendothelial system and subsequent behavior of its cells toward other colloids].

4. Cold-precipitation by heparin of a protein in rabbit and human plasma.

5. Effect of carboxylic and amino acids on fibrinolysis produced by plasmin, plasminogen activator and proteases.

6. Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity.

7. The fibrin plate method for estimating fibrinolytic activity.

8. Studies on the generalized Shwartzman reaction. IV. Prevention of the local and generalized Shwartzman reactions with heparin.

9. Studies on the generalized Shwartzman reaction. II. The production of bilateral cortical necrosis of the kidneys by a single injection of bacterial toxin in rabbits previously treated with thorotrast or trypan blue.

10. Studies on the generalized Shwartzman reaction: I. General observations concerning the phenomenon.

1. STUDIES ON THE PATHOGENESIS OF ACUTE INFLAMMATION. V. AN ASSESSMENT OF FACTORS THAT INFLUENCE IN VITRO THE PHAGOCYTIC AND ADHESIVE PROPERTIES OF LEUKOCYTES OBTAINED FROM RABBIT PERITONEAL EXUDATE.

Review 2. Glomerular fibrin deposition and removal.

Review 3. Disseminated intravascular coagulation: a review.

Review 4. [Principles of pathological-anatomical diagnosis of consumption coagulopathy].

5. In vivo behavior of fibrinogen fragment D in experimental renal, hepatic and reticuloendothelial dysfunction.

6. Endotoxin and acute renal failure associated with obstructive jaundice.

7. [Local and generalized Sanarelli-Shwartzman phenomenon in the human fetal organism].

8. [Studies on the pathology of shock in man. IV. Pathomorphology of the shock liver].

9. The effect of thorotrast and cortisone on renal cortical fibrinolytic activity in the rabbit.

10. Corticosteroids and the generalized Shwartzman reaction. Mechanisms of sensitization in the rabbit.