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Literature DB >> 1446252

Tracheal epithelium in culture: a model for toxicity testing of inhaled molecules.

S Romet-Haddad¹, F Marano, C Blanquart, A Baeza-Squiban.

Abstract

Rabbit trachea primary cultures have been developed as a model to evaluate the toxicity of noxious airborne pollutants. A mucociliary epithelium has been restored in vitro on collagen gel. Several general cytotoxicity assays (viability and growth inhibition) permit a first assessment for the acute toxicity of the tested molecules. More specific criteria such as measurement of the integrity of the epithelial barrier and inhibition of ciliary beat frequency allow to determine a specific impact of xenobiotics on the mucociliary epithelium in culture.

Entities: Disease

Mesh：

Substances：

Year: 1992 PMID： 1446252 DOI： 10.1007/bf00130521

Source DB: PubMed Journal: Cell Biol Toxicol ISSN： 0742-2091 Impact factor: 6.691

12 in total

1. The assessment of tobacco smoke toxicity in organ culture. II. Ultrastructural studies on the immediate response of foetal rabbit tracheal epithelium to short-term exposures of whole smoke.

Authors: P Davies; G S Kistler
Journal: Experientia Date: 1975-06-15

2. Respiratory tract epithelium in primary culture: Effects of ciliotoxic compounds.

Authors: S Romet; A Dubreuil; A Baeza; A Moreau; D Schoevaert; F Marano
Journal: Toxicol In Vitro Date: 1990 Impact factor: 3.500

3. Dynamic image analysis applied to the study of ciliary beat on cultured ciliated epithelial cells from rabbit trachea.

Authors: S Romet; D Schoevaert; F Marano
Journal: Biol Cell Date: 1991 Impact factor: 4.458

4. The effect of 3-methylcholanthrene on rat trachea in organ culture.

Authors: L Palekar; M Kuschner; S Laskin
Journal: Cancer Res Date: 1968-10 Impact factor: 12.701

5. Use of hamster tracheal organ cultures for assessing the cocarcinogenic effects of inorganic particulates on the respiratory epithelium.

Authors: B T Mossman; J E Craighead
Journal: Prog Exp Tumor Res Date: 1979

7. Effect of mineral particles containing iron on primary cultures of rabbit tracheal epithelial cells: possible implication of oxidative stress.

Authors: C Guilianelli; A Baeza-Squiban; E Boisvieux-Ulrich; O Houcine; R Zalma; C Guennou; H Pezerat; F Marano
Journal: Environ Health Perspect Date: 1993-10 Impact factor: 9.031

7 in total

Tracheal epithelium in culture: a model for toxicity testing of inhaled molecules.

1. The assessment of tobacco smoke toxicity in organ culture. II. Ultrastructural studies on the immediate response of foetal rabbit tracheal epithelium to short-term exposures of whole smoke.

2. Respiratory tract epithelium in primary culture: Effects of ciliotoxic compounds.

3. Dynamic image analysis applied to the study of ciliary beat on cultured ciliated epithelial cells from rabbit trachea.

4. The effect of 3-methylcholanthrene on rat trachea in organ culture.

5. Use of hamster tracheal organ cultures for assessing the cocarcinogenic effects of inorganic particulates on the respiratory epithelium.

Review 6. Tracheal epithelial cell transformation: a model system for studies on neoplastic progression.

7. Primary cultures of tracheal epithelial cells for the evaluation of respiratory toxicity.

8. Neoplastic transformation of primary tracheal epithelial cell cultures.

Review 9. In vitro analysis of multistage carcinogenesis.

Review 10. Deposition and clearance of inhaled particles.

1. Induction of ciliated cells from avian embryonic stem cells using three-dimensional matrix.

2. Extracellular matrix-dependent differentiation of rabbit tracheal epithelial cells in primary culture.

3. Ion transport mechanisms for smoke inhalation-injured airway epithelial barrier.

4. Toxic effects of mechlorethamine on mammalian respiratory mucociliary epithelium in primary culture.

5. Ciliogenesis in cryopreserved mammalian tracheal epithelial cells cultured at the air-liquid interface.

6. Tracheal Morphologic and Protein Alterations FollowingShort-Term Cigarette Mainstream Smoke Exposure to Rats.

7. Effect of mineral particles containing iron on primary cultures of rabbit tracheal epithelial cells: possible implication of oxidative stress.