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Literature DB >> 14449901

Growth characteristics of monkey kidney cell strains LLC-MK1, LLC-MK2, and LLC-MK2(NCTC-3196) and their utility in virus research.

Abstract

The establishment of two strains of rhesus monkey kidney cells in continuous tissue culture, the development of a subline adapted to chemically defined medium, and the isolation of several clonal derivatives were described. Growth characteristics, chromosome numbers, malignant potentiality, and freeze storage data are presented. The cells were studied for their sensitivity to a large number of viruses and were extensively compared with primary cultures of monkey kidney cells for sensitivity to poliovirus. The cell strains were not sensitive to all the viruses which could be grown in primary cultures of the same tissue but were susceptible to most of them. In some instances an advantage to the use of the cell strain for certain viruses was noted.

Entities: CellLine Gene Species

Keywords: KIDNEY; MONKEYS; TISSUE CULTURE; VIRUSES/culture

Mesh：

Year: 1962 PMID： 14449901 PMCID： PMC2137539 DOI： 10.1084/jem.115.5.903

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

1. Fatal bulbospinal paralytic poliomyelitis due to ECHO 11 virus.

Authors: A J STEIGMAN; M M LIPTON
Journal: JAMA Date: 1960-09-10 Impact factor: 56.272

2. Some virus isolations from common colds. III. Cytopathic effects in tissue cultures.

Authors: D A TYRRELL; R PARSONS
Journal: Lancet Date: 1960-01-30 Impact factor: 79.321

3. The Coe virus: an apparently new virus recovered from patients with mild respiratory disease.

Authors: E H LENNETTE; V L FOX; N J SCHMIDT; J O CULVER
Journal: Am J Hyg Date: 1958-11

4. Tumors induced in hamsters by injection of rhesus monkey kidney cell extracts.

Authors: B E EDDY; G S BORMAN; W H BERKELEY; R D YOUNG
Journal: Proc Soc Exp Biol Med Date: 1961-05

5. The vacuolating virus, S.V. 40.

Authors: B H SWEET; M R HILLEMAN
Journal: Proc Soc Exp Biol Med Date: 1960-11

6. Seven viruses isolated from the vervet monkey.

Authors: H MALHERBE; R HARWIN
Journal: Br J Exp Pathol Date: 1957-10

7. New viral agents recovered from tissue cultures of monkey kidney cells. II. Problems of isolation and identification.

Authors: R N HULL; J R MINNER
Journal: Ann N Y Acad Sci Date: 1957-04-19 Impact factor: 5.691

8. The adaptation of additional lines of NCTC clone 929(strain L) cells to chemically defined protein-free medium NCTC 109.

Authors: W T McQUILKIN; V J EVANS; W R EARLE
Journal: J Natl Cancer Inst Date: 1957-11 Impact factor: 13.506

9. New viral agents recovered from tissue cultures of monkey kidney cells. I. Origin and properties of cytopathogenic agents S.V.1, S.V.2, S.V.4, S.V.5, S.V.6, S.V.11, S.V.12 and S.V.15.

Authors: R N HULL; J R MINNER; J W SMITH
Journal: Am J Hyg Date: 1956-03

7. Growth of Chlamydia psittaci strain meningopneumonitis in mouse L cells cultivated in a defined medium in spinner cultures.

Authors: S J Morrison; H M Jenkin
Journal: In Vitro Date: 1972 Sep-Oct

Growth characteristics of monkey kidney cell strains LLC-MK1, LLC-MK2, and LLC-MK2(NCTC-3196) and their utility in virus research.

1. Fatal bulbospinal paralytic poliomyelitis due to ECHO 11 virus.

2. Some virus isolations from common colds. III. Cytopathic effects in tissue cultures.

3. The Coe virus: an apparently new virus recovered from patients with mild respiratory disease.

4. Tumors induced in hamsters by injection of rhesus monkey kidney cell extracts.

5. The vacuolating virus, S.V. 40.

6. Seven viruses isolated from the vervet monkey.

7. New viral agents recovered from tissue cultures of monkey kidney cells. II. Problems of isolation and identification.

8. The adaptation of additional lines of NCTC clone 929(strain L) cells to chemically defined protein-free medium NCTC 109.

9. New viral agents recovered from tissue cultures of monkey kidney cells. I. Origin and properties of cytopathogenic agents S.V.1, S.V.2, S.V.4, S.V.5, S.V.6, S.V.11, S.V.12 and S.V.15.

10. ACUTE ASCENDING MYELITIS FOLLOWING A MONKEY BITE, WITH THE ISOLATION OF A VIRUS CAPABLE OF REPRODUCING THE DISEASE.

1. THE SENSITIVITY OF GRIVET MONKEY KIDNEY CELL LINE BS-C-1 FOR PROPAGATION AND ISOLATION OF CERTAIN HUMAN VIRUSES.

2. USE OF MICRO TECHNIQUE FOR SERUM NEUTRALIZATION AND VIRUS IDENTIFICATION.

3. SUSCEPTIBILITY OF THE LLC-MK2 LINE OF MONKEY KIDNEY CELLS TO HUMAN ENTEROVIRUSES.

4. CHARACTERIZATION OF GROWTH OF RUBELLA VIRUS IN LLC-MK 2 CELLS.

5. Hemoagglutination and hemagglutination inhibition tests with enterovirus type 70.

6. Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference.

7. Growth of Chlamydia psittaci strain meningopneumonitis in mouse L cells cultivated in a defined medium in spinner cultures.

8. Systematic assembly of a full-length infectious clone of human coronavirus NL63.

9. Effect of vancomycin on the growth of psittacosis-trachoma agents cultivated in eggs and cell culture.

10. Enhancement of infectivity of poliovirus RNA with diethylaminoethyl-dextran (DEAE-D).