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Literature DB >> 1444397

Screening for microorganisms producing D-malate from maleate.

M J van der Werf¹, W J van den Tweel, S Hartmans.

Abstract

More than 300 microorganisms were screened for their ability to convert maleate into D-malate as a result of the action of maleate hydratase. Accumulation of fumarate during incubation of permeabilized cells with maleate was shown to be indicative of one of the two enzymes known to transform maleate. The ratio in which fumarate and malate accumulated could be used to estimate the enantiomeric composition of the malate formed. Many strains (n = 128) were found to be capable of converting maleate to D-malate with an enantiomeric purity of more than 97%. Pseudomonas pseudoalcaligenes NCIMB 9867 was selected for more detailed studies. Although this strain was not able to grow on maleate, permeabilized cells were able to degrade maleate to undetectable levels, with a concomitant formation of D-malate. The D-malate was formed with an enantiomeric purity of more than 99.97%.

Entities: Chemical Species

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Year: 1992 PMID： 1444397 PMCID： PMC183018 DOI： 10.1128/aem.58.9.2854-2860.1992

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

22 in total

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Authors: J R STERN
Journal: Biochim Biophys Acta Date: 1963-02-05

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Authors: E J BEHRMAN; R Y STANIER
Journal: J Biol Chem Date: 1957-10 Impact factor: 5.157

3. Metabolism of Styrene Oxide and 2-Phenylethanol in the Styrene-Degrading Xanthobacter Strain 124X.

Authors: S Hartmans; J P Smits; M J van der Werf; F Volkering; J A de Bont
Journal: Appl Environ Microbiol Date: 1989-11 Impact factor: 4.792

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Authors: M Hayashi; T Unemoto
Journal: Biochim Biophys Acta Date: 1966-08-10

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Authors: C L Stahl; G A Sojka
Journal: Biochim Biophys Acta Date: 1973-02-28

6. Evidence for isofunctional enzymes used in m-cresol and 2,5-xylenol degradation via the gentisate pathway in Pseudomonas alcaligenes.

Authors: C L Poh; R C Bayly
Journal: J Bacteriol Date: 1980-07 Impact factor: 3.490

7. Studies on succinate dehydrogenase. II. On the nature of the reaction of competitive inhibitors and substrates with succinate dehydrogenase.

Authors: D V Dervartanian; C Veeger
Journal: Biochim Biophys Acta Date: 1965-09-20

8. Microbial metabolism of the pyridine ring. Metabolism of 2- and 3-hydroxypyridines by the maleamate pathway in Achromobacter sp.

Authors: R B Cain; C Houghton; K A Wright
Journal: Biochem J Date: 1974-05 Impact factor: 3.857

5. The activity of the C4-dicarboxylic acid chemoreceptor of Pseudomonas aeruginosa is controlled by chemoattractants and antagonists.

Authors: David Martín-Mora; Álvaro Ortega; Francisco J Pérez-Maldonado; Tino Krell; Miguel A Matilla
Journal: Sci Rep Date: 2018-02-01 Impact factor: 4.379

5 in total

Screening for microorganisms producing D-malate from maleate.

1. Enzymic activation and cleavage of D- and L-malate.

2. The bacterial oxidation of nicotinic acid.

3. Metabolism of Styrene Oxide and 2-Phenylethanol in the Styrene-Degrading Xanthobacter Strain 124X.

4. The presence of D-malate dehydrogenase (D-malate:NAD oxidoreductase) in Serratia marcescens.

5. Growth of Rhodopseudomonas capsulata on L- and D-malic acid.

6. Evidence for isofunctional enzymes used in m-cresol and 2,5-xylenol degradation via the gentisate pathway in Pseudomonas alcaligenes.

7. Studies on succinate dehydrogenase. II. On the nature of the reaction of competitive inhibitors and substrates with succinate dehydrogenase.

8. Microbial metabolism of the pyridine ring. Metabolism of 2- and 3-hydroxypyridines by the maleamate pathway in Achromobacter sp.

9. [Effects of alcohol drinking on mental task performance].

10. Equilibrium constants of several reactions involved in the fermentation of glutamate.

1. Purification and Characterization of Maleate Hydratase from Pseudomonas pseudoalcaligenes.

2. Identification of a Specific Maleate Hydratase in the Direct Hydrolysis Route of the Gentisate Pathway.

3. Regulation of aerobic and anaerobic D-malate metabolism of Escherichia coli by the LysR-type regulator DmlR (YeaT).

4. Synthetic and quantum chemical study on the regioselective addition of amines to methyl maleamate.

5. The activity of the C4-dicarboxylic acid chemoreceptor of Pseudomonas aeruginosa is controlled by chemoattractants and antagonists.