Literature DB >> 1444320

Novel nucleoside strategies for anti-HIV and anti-HSV therapy.

P A Herdewijn1.   

Abstract

This mini-review describes the structure-activity relationships of several series of new nucleoside analogues. It also points to the possibilities of finding new molecular modifications which could lead to antivirals with activity both against human immunodeficiency viruses (HIV) and herpesviruses.

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Year:  1992        PMID： 1444320     DOI： 10.1016/0166-3542(92)90052-7

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  3 in total

1.  Ab initio molecular dynamics studies on HIV-1 reverse transcriptase triphosphate binding site: implications for nucleoside-analog drug resistance.

Authors:  F Alber; P Carloni
Journal:  Protein Sci       Date:  2000-12       Impact factor: 6.725

Review 2.  Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry.

Authors:  V Nair; T S Jahnke
Journal:  Antimicrob Agents Chemother       Date:  1995-05       Impact factor: 5.191

3.  Pharmacokinetics and distribution over the blood-brain barrier of zalcitabine (2',3'-dideoxycytidine) and BEA005 (2', 3'-dideoxy-3'-hydroxymethylcytidine) in rats, studied by microdialysis.

Authors:  N Borg; L Ståhle
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191
  3 in total

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