Literature DB >> 1444313

Low-dose trimethoprim-sulfamethoxazole alone and in association with zidovudine for prevention and treatment of murine Pneumocystis carinii pneumonia.

M Brun-Pascaud1, P M Girard, J J Pocidalo.   

Abstract

Low-dose trimethoprim-sulfamethoxazole (TMP-SMX) alone was found to be as effective as low-dose TMP-SMX plus zidovudine and standard-dose TMP-SMX alone in preventing and treating Pneumocystis carinii pneumonia (PCP) in an immunosuppressed-rat model. Zidovudine alone had no preventive or curative effect on PCP. We conclude that the initially reported reduced incidence of PCP in human immunodeficiency virus-infected patients treated with zidovudine alone is not due to anti-P. carinii activity of zidovudine. Furthermore, the clinical efficacy of low-dose TMP-SMX for the prevention and treatment of PCP should be further investigated.

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Year:  1992        PMID： 1444313      PMCID： PMC245497          DOI： 10.1128/AAC.36.10.2328

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Pneumocystis carinii: new separation method from lung tissue.

Authors:  P D Walzer; M E Rutledge; K Yoneda; B J Stahr
Journal:  Exp Parasitol       Date:  1979-06       Impact factor: 2.011

2.  Efficacy of zidovudine in preventing relapses of Salmonella bacteremia in AIDS.

Authors:  D Salmon; P Detruchis; C Leport; E Bouvet; D Karam; M C Meyohas; J P Coulaud; J L Vildé
Journal:  J Infect Dis       Date:  1991-02       Impact factor: 5.226

3.  Low-dose co-trimoxazole for prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus disease.

Authors:  J Ruskin; M LaRiviere
Journal:  Lancet       Date:  1991-02-23       Impact factor: 79.321

4.  Synergistic anti-Pneumocystis carinii effects of erythromycin and sulfisoxazole.

Authors:  W T Hughes; J T Killmar
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1991

5.  Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo.

Authors:  S F Queener; M S Bartlett; J D Richardson; M M Durkin; M A Jay; J W Smith
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

6.  Low-dose intermittent trimethoprim-sulfamethoxazole for prevention of Pneumocystis carinii pneumonia in patients with human immunodeficiency virus infection.

Authors:  G P Wormser; H W Horowitz; F P Duncanson; G Forseter; K Javaly; S K Alampur; S A Gilroy; T Lenox; A Rappaport; R B Nadelman
Journal:  Arch Intern Med       Date:  1991-04

7.  Factors influencing zidovudine efficacy when administered at early stages of Friend virus infection in mice.

Authors:  M Sinet; B Desforges; O Launay; J N Colin; J J Pocidalo
Journal:  Antiviral Res       Date:  1991-09       Impact factor: 5.970

8.  The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.

Authors:  M A Fischl; D D Richman; M H Grieco; M S Gottlieb; P A Volberding; O L Laskin; J M Leedom; J E Groopman; D Mildvan; R T Schooley
Journal:  N Engl J Med       Date:  1987-07-23       Impact factor: 91.245

9.  Pentamidine aerosol in prophylaxis and treatment of murine Pneumocystis carinii pneumonia.

Authors:  P M Girard; M Brun-Pascaud; R Farinotti; L Tamisier; S Kernbaum
Journal:  Antimicrob Agents Chemother       Date:  1987-07       Impact factor: 5.191

10.  Safety and efficacy of sulfamethoxazole and trimethoprim chemoprophylaxis for Pneumocystis carinii pneumonia in AIDS.

Authors:  M A Fischl; G M Dickinson; L La Voie
Journal:  JAMA       Date:  1988-02-26       Impact factor: 56.272
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