Literature DB >> 1443350

Albendazole in the treatment of onchocerciasis: double-blind clinical trial in Venezuela.

B L Cline1, J L Hernandez, F J Mather, R Bartholomew, S N De Maza, S Rodulfo, C A Welborn, M L Eberhard, J Convit.   

Abstract

A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection. Forty-nine patients (26 treated and 23 controls) received a 10-day course of albendazole (400 mg/day) or a placebo. Consistent with the excellent tolerance observed, albendazole did not kill microfilariae. However, analysis of changes in microfilarial densities (mf/mg of skin) over one year showed that albendazole was active against O. volvulus, presumably by interfering with embryogenesis. The nature, degree, and duration of this effect remain to be determined.

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Year:  1992        PMID： 1443350     DOI： 10.4269/ajtmh.1992.47.512

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  8 in total

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Authors:  N de Silva; H Guyatt; D Bundy
Journal:  Drugs       Date:  1997-05       Impact factor: 9.546

2.  Clinical picture and outcome of Serious Adverse Events in the treatment of Onchocerciasis.

Authors:  Kwablah Awadzi
Journal:  Filaria J       Date:  2003-10-24

3.  Development and validation of an Onchocerca ochengi adult male worm gerbil model for macrofilaricidal drug screening.

Authors:  Fidelis Cho-Ngwa; Glory Enjong Mbah; Rene Bilingwe Ayiseh; Emmanuel Menang Ndi; Elvis Monya; Irene Memeh Tumanjong; Evans Ngandung Mainsah; Judy Sakanari; Sara Lustigman
Journal:  PLoS Negl Trop Dis       Date:  2019-07-01

4.  Effects of diethylcarbamazine and ivermectin treatment on Brugia malayi gene expression in infected gerbils (Meriones unguiculatus).

Authors:  Mary J Maclean; W Walter Lorenz; Michael T Dzimianski; Christopher Anna; Andrew R Moorhead; Barbara J Reaves; Adrian J Wolstenholme
Journal:  Parasitol Open       Date:  2019-03-08

5.  UMF-078: A modified flubendazole with potent macrofilaricidal activity against Onchocerca ochengi in African cattle.

Authors:  Barend M Dec Bronsvoort; Benjamin L Makepeace; Alfons Renz; Vincent N Tanya; Lawrence Fleckenstein; David Ekale; Alexander J Trees
Journal:  Parasit Vectors       Date:  2008-06-20       Impact factor: 3.876

Review 6.  Research for new drugs for elimination of onchocerciasis in Africa.

Authors:  Annette C Kuesel
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2016-05-19       Impact factor: 4.077

7.  Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis.

Authors:  Joseph D Turner; Raman Sharma; Ghaith Al Jayoussi; Hayley E Tyrer; Joanne Gamble; Laura Hayward; Richard S Priestley; Emma A Murphy; Jill Davies; David Waterhouse; Darren A N Cook; Rachel H Clare; Andrew Cassidy; Andrew Steven; Kelly L Johnston; John McCall; Louise Ford; Janet Hemingway; Stephen A Ward; Mark J Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-23       Impact factor: 11.205

8.  Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.

Authors:  Jong-Yil Chai; Bong-Kwang Jung; Sung-Jong Hong
Journal:  Korean J Parasitol       Date:  2021-06-21       Impact factor: 1.341
  8 in total

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