Literature DB >> 14428139

Decarboxylase inhibition and blood pressure reduction by alpha-methyl-3,4-dihydroxy-DL-phenylalanine.

J A OATES, L GILLESPIE, S UDENFRIEND, A SJOERDSMA.   

Abstract

alpha-Methyl-3,4-dihydroxy-DLphenylalanine has been found to be an effective inhibitor of aromatic amino acid decarboxylation in man. This was shown by decreased formation of serotonin, tryptamine, and tyramine from the precursor amino acids. Reduction of amine biosynthesis is associated with lowering of blood pressure in hypertensive patients and a transient sedative effect.

Entities:  

Keywords:  BLOOD PRESSURE/pharmacology; DESMOLASES/metabolism; PHENYLALANINE/related compounds

Mesh：

Substances：

Year:  1960        PMID： 14428139     DOI： 10.1126/science.131.3417.1890

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  39 in total

1.  Editorial: Side effects of methyldopa.

Authors: 
Journal:  Br Med J       Date:  1975-03-22

2.  GUANETHIDINE AND METHYLDOPA: A HAEMODYNAMIC STUDY.

Authors:  D A CHAMBERLAIN; J HOWARD
Journal:  Br Heart J       Date:  1964-07

3.  METHYLDOPA IN TREATMENT OF SEVERE TOXAEMIA OF PREGNANCY.

Authors:  S F HANS; H KOPELMAN
Journal:  Br Med J       Date:  1964-03-21

4.  HAEMODYNAMIC STUDIES WITH METHYLDOPA: EFFECT ON CARDIAC OUTPUT AND RESPONSE TO PRESSOR AMINES.

Authors:  C T DOLLERY; M HARINGTON; J V HODGE
Journal:  Br Heart J       Date:  1963-09

5.  [CATECHOLAMINE DETERMINATION IN THE HUMAN URINE DURING AND AFTER METHYLDOPA ADMINISTRATION].

Authors:  K SCHLOSSMANN; K D BOCK; G KRONEBERG
Journal:  Klin Wochenschr       Date:  1964-05-01

6.  Parkinsonism occurring with methyldopa treatment.

Authors:  B M GRODEN
Journal:  Br Med J       Date:  1963-04-13

7.  Treatment of severe hypertension with methyldopa.

Authors:  M HAMILTON; H KOPELMAN
Journal:  Br Med J       Date:  1963-01-19

8.  Hypotensive action methyldopa.

Authors:  H SMIRK
Journal:  Br Med J       Date:  1963-01-19

9.  Another hypotensive agent--methyldopa.

Authors:  D DALEY; B EVANS
Journal:  Br Med J       Date:  1962-07-21

Review 10.  Clinical pharmacokinetics of methyldopa.

Authors:  E Myhre; H E Rugstad; T Hansen
Journal:  Clin Pharmacokinet       Date:  1982 May-Jun       Impact factor: 6.447
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