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Literature DB >> 14424649

Inhibition of mast cell disruption and histamine release in rat anaphylaxis in vitro. Comparison with compound 48/80.

Abstract

In vitro anaphylactic reaction causes mast cell damage and histamine release from rat tissue. Histamine release is correlated with mast cell damage and both phenomena are simultaneously inhibited by various metabolic inhibitors, antipyretics, calcium lack and previous heating of the tissue at 45 degrees . The mast cell damage produced by antigen in sensitized rat tissues is morphologically similar to that caused by compound 48/80, both agents causing extrusion of granules. Mast cell damage and histamine release induced by antigen or by compound 48/80 are inhibited alike by several substances and conditions. It is suggested that in rats the histamine-releasing mechanism of the antigen-antibody reaction in anaphylaxis is very similar to that of compound 48/80.

Entities: Chemical Species

Keywords: ALLERGY/experimental; HISTAMINE; MAST CELLS/pharmacology

Mesh：

Substances：

Year: 1960 PMID： 14424649 PMCID： PMC1481977 DOI： 10.1111/j.1476-5381.1960.tb01213.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

7 in total

1. The mechanism of anaphylaxis: specificity of antigen-induced mast cell damage in anaphylaxis in the guinea pig.

Authors: J H HUMPHREY; I MOTA
Journal: Immunology Date: 1959-01 Impact factor: 7.397

2. Studies on the in vitro action of compound 48-80, a formaldehyde condensation product, on rat mast-cells.

Authors: L C JUNQUEIRA; B BEIGUELMAN
Journal: Tex Rep Biol Med Date: 1955

3. Leucine aminopeptidase activity in mast cells.

Authors: O BRAUN-FALCO; K SALFELD
Journal: Nature Date: 1959-01-03 Impact factor: 49.962

4. Systemic and local anaphylaxis in the albino rat.

Authors: J FREUND; M M LIPTON; S H STONE
Journal: J Immunol Date: 1956-12 Impact factor: 5.422

5. Effect of antigen and organic bases on intracellular histamine in guinea-pig lung.

Authors: J L MONGAR; H O SCHILD
Journal: J Physiol Date: 1956-01-27 Impact factor: 5.182

6. The intracellular distribution of histamine.

Authors: J H COPENHAVER; M E NAGLER; A GOTH
Journal: J Pharmacol Exp Ther Date: 1953-12 Impact factor: 4.030

7. Protamine-like property of compounds 48/80 and stilbamidine and their action on mast cells.

Authors: I MOTA; W T BERALDO; C U JUNQUEIRA
Journal: Proc Soc Exp Biol Med Date: 1953-07

7 in total

14 in total

1. Attenuation of exercise induced asthma by local hyperthermia.

Authors: S L Johnston; D Perry; S O'Toole; Q A Summers; S T Holgate
Journal: Thorax Date: 1992-08 Impact factor: 9.139

Review 2. [ENZYMATIC PROCESSES IN THE PATHOGENESIS OF ALLERGIC REACTIONS].

Authors: W RAAB; E KAISER
Journal: Klin Wochenschr Date: 1965-04-01

3. In vitro studies of reversed anaphylaxis with rat cells.

Authors: J H HUMPHREY; K F AUSTEN; H J RAPP
Journal: Immunology Date: 1963-05 Impact factor: 7.397

4. Mast cells and anaphylaxis.

Authors: R KELLER
Journal: Experientia Date: 1962-06-15

5. Histamine release by bee venom phospholipase a and mellitin in the rat.

Authors: A M Rothschild
Journal: Br J Pharmacol Chemother Date: 1965-08

6. Dissociation of the inhibitory activities of iodoacetamide (IAc) on specific histamine release and lactate production in human leucocytes.

Authors: J J Pruzansky; R Patterson
Journal: Immunology Date: 1974-04 Impact factor: 7.397

7. The inhibitory effect of phenothiazine stains on rat and guinea-pig mast cell damage induced by antihistamines and compound 48-80.

Authors: I Vugman; M L do Prado
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000