Literature DB >> 14416176

Serine derivative with antitumor activity.

I LEVI, H BLONDAL, E LOZINSKI.   

Abstract

The sodium salt of N-dichloroacetyl-DL-serine depresses the growth of sarcoma-37 in mice, causing complete regressions of the tumor. The compound is nontoxic to mice in doses up to 4 gm/kg of body weight. The animals do not lose body weight and show no alteration in the formed elements of the blood or in hemoglobin content.

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Keywords:  ANTINEOPLASTIC AGENTS/pharmacology; SERINE/related compounds

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Year:  1960        PMID: 14416176     DOI: 10.1126/science.131.3401.666

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  1 in total

1.  Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane.

Authors:  W Schwarz; R W Hartmann; J Engel; M R Schneider; H Schönenberger
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553

  1 in total

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