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Literature DB >> 14413831

Inactivation of endotoxin by a humoral component. IV. Alteration in the immunological properties of typhoid endotoxin.

Abstract

The immunological properties of typhoid endotoxin were investigated after incubating it with serum under conditions in which EDC (endotoxin-detoxifying component) was operative. Brief interaction of endotoxin in vitro with this system in serum (human, rabbit, mouse) abolished its antigenicity for rabbits. Suitable modification of the host permitted separate elicitation of toxic and antigenic responses to typhoid endotoxin. Endotoxin altered by EDC was still capable of precipitating specific antibody; moreover, it did so in a manner which resembled that of the haptenic polysaccharide.

Entities: Chemical Species

Keywords: TYPHOID/immunology

Mesh：

Substances：

Year: 1959 PMID： 14413831 PMCID： PMC2137028 DOI： 10.1084/jem.110.5.731

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

18 in total

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Authors: J E STAUCH; A G JOHNSON
Journal: J Immunol Date: 1959-03 Impact factor: 5.422

2. Studies on the O antigen of Salmonella typhosa. I. Purification of the antigen.

Authors: M E WEBSTER; J F SAGIN; M LANDY; A G JOHNSON
Journal: J Immunol Date: 1955-06 Impact factor: 5.422

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Authors: I L BENNETT; L E CLUFF
Journal: Pharmacol Rev Date: 1957-12 Impact factor: 25.468

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Authors: M HO; E H KASS
Journal: J Lab Clin Med Date: 1958-02

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Authors: M LANDY; R C SKARNES; F S ROSEN; R J TRAPANI; M J SHEAR
Journal: Proc Soc Exp Biol Med Date: 1957-12

6. Studies on the mechanism of the immunological paralysis induced in mice by pneumococcal polysaccharides.

Authors: L D FELTON; G KAUFFMANN; B PRESCOTT; B OTTINGER
Journal: J Immunol Date: 1955-01 Impact factor: 5.422

7. The preparation and properties of a specific polysaccharide from Bact. typhosum Ty(2): With an addendum by J. St L. Philpot, From the Department of Biochemistry, Oxford.

Authors: G G Freeman
Journal: Biochem J Date: 1942-04 Impact factor: 3.857

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Authors: M LANDY; R J TRAPANI; F S ROSEN
Journal: J Clin Invest Date: 1960-02 Impact factor: 14.808

3. Alteration and restoration of endotoxin activity after complexing with plasma proteins.

Authors: J A Rudbach; A G Johnson
Journal: J Bacteriol Date: 1966-10 Impact factor: 3.490

4. Isolation from human serum of an inactivator of bacterial lipopolysaccharide.

Authors: K J Johnson; P A Ward; S Goralnick; M J Osborn
Journal: Am J Pathol Date: 1977-09 Impact factor: 4.307

5. Further studies on passive transfer of tolerance to pyrogenicity of bacterial endotoxin. The febrile and leucopenic responses.

Authors: H H FREEDMAN
Journal: J Exp Med Date: 1960-10-01 Impact factor: 14.307

6. EFFECTS OF BACTERIAL ENDOTOXINS ON METABOLISM : III. NITROGEN EXCRETION AFTER ACTH AS AN ASSAY FOR ENDOTOXIN.

Authors: L J Berry; D S Smythe
Journal: J Exp Med Date: 1961-01-01 Impact factor: 14.307

6 in total