A note on the demyelination produced in hens by dialkylfluoridates.

Hens were treated with organophosphorus compounds until signs of neurotoxicity developed. The sciatic nerves, spinal cord, and medulla were then examined histologically by the Marchi method, to determine the extent and distribution of demyelination. The lesions were proportional to the dose of compound injected, and the spinal cord was more sensitive than the sciatic nerves. It is suggested that the spinal cord, and not the sciatic nerves, is the main site of damage in clinical paralysis following dyflos poisoning.