Literature DB >> 14411269

Stimulation of amino acid transport in isolated diaphragm by growth hormone added in vitro.

J L KOSTYO, J HOTCHKISS, E KNOBIL.   

Abstract

The influence of the pituitary on the transport of alpha-aminoisobutyric acid-1-C(14) into the cells of isolated rat diaphragm was investigated. Hypophysectomy results in a lower-than-normal rate of alpha-aminoisobutyric acid-1-C(14) penetration into muscle. Adding either simian or bovine growth hormone preparations to the incubation medium in concentrations of 2.5 to 25 microg/ml of medium resulted in a doubling of the alpha-aminoisobutyric acid-l-C(14) penetration rate. The stimulatory effect was minimized when the hormone concentration was reduced to 0.25 microg/ml of medium.

Entities:  

Keywords:  AMINO ACIDS/metabolism; MUSCLES/metabolism; SOMATOTROPIN/pharmacology

Mesh：

Substances：

Year:  1959        PMID： 14411269     DOI： 10.1126/science.130.3389.1653

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Genetic parameters of protein metabolism and growth in mice.

Authors:  G A Gall; W H Kyle; J C Rogler; V L Anderson
Journal:  Genetics       Date:  1967-06       Impact factor: 4.562

Review 2.  Resistance exercise overtraining and overreaching. Neuroendocrine responses.

Authors:  A C Fry; W J Kraemer
Journal:  Sports Med       Date:  1997-02       Impact factor: 11.136

3.  Evaluation of the rate-limiting steps in the pathway of glucose metabolism in kidney cortex of normal, diabetic, cortisone-treated and growth hormone-treated rats.

Authors:  P K Joseph; K Subrahmanyam
Journal:  Biochem J       Date:  1972-08       Impact factor: 3.857

4.  Effect of insulin on protein synthesis in skeletal muscle of an isolated perfused preparation of rat hemicorpus.

Authors:  L S Jefferson; J O Koehler; H E Morgan
Journal:  Proc Natl Acad Sci U S A       Date:  1972-04       Impact factor: 11.205

5.  Amino acid requirement for the growth-hormone stimulation of incorporation of precursors into protein and nucleic acids of liver slices.

Authors:  M J Clemens; A Korner
Journal:  Biochem J       Date:  1970-10       Impact factor: 3.857

6.  Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.

Authors:  Yong Fan; Ram K Menon; Pinchas Cohen; David Hwang; Thomas Clemens; Douglas J DiGirolamo; John J Kopchick; Derek Le Roith; Massimo Trucco; Mark A Sperling
Journal:  J Biol Chem       Date:  2009-05-21       Impact factor: 5.157

Review 7.  Effects of growth hormone on body composition and bone metabolism.

Authors:  A L Carrel; D B Allen
Journal:  Endocrine       Date:  2000-04       Impact factor: 3.925
  7 in total

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