Literature DB >> 14409499

Comparison of effects of valyl(3)-oxytocin and syntocinon on the cardiovascular system of man.

A H KITCHIN, H KONZETT, M PICKFORD.   

Abstract

Valyl(3)-oxytocin has similar circulatory effects in man to those of Syntocinon (synthetic oxytocin). On intravenous administration, it caused a rise in limb blood flow and in pulse rate and a fall in blood pressure. It had a direct vasodilator effect on limb blood vessels. Valyl(3)-oxytocin was 1.5 to 2 times more potent than Syntocinon in terms of its circulatory effect in man. The circulatory effects of valyl(3)-oxytocin were less readily antagonized by vasopressin than are those of Syntocinon.

Entities:  

Keywords:  CARDIOVASCULAR SYSTEM/pharmacology; OXYTOCIN/pharmacology; OXYTOCIN/related compounds

Mesh：

Substances：

Year:  1959        PMID： 14409499      PMCID： PMC1481894          DOI： 10.1111/j.1476-5381.1959.tb00965.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  4 in total

1.  Some actions of oxytocin on the cardiovascular system in man.

Authors:  A H KITCHIN; S M LLOYD; M PICKFORD
Journal:  Clin Sci       Date:  1959-08       Impact factor: 6.124

2.  Effect of valyl-oxytocin on the human subject.

Authors:  C N SMYTH
Journal:  Br Med J       Date:  1958-04-12

3.  Synthesis and biological activity of a new potent analogue of oxytocin.

Authors:  B BERDE; R A BOISSONNAS; S GUTTMANN; P A JAQUENOUD; H KONZETT; J P WALLER
Journal:  Nature       Date:  1956-08-04       Impact factor: 49.962

4.  Some pharmacological actions of four synthetic analogues of oxytocin.

Authors:  B BERDE; W DOEPFNER; H KONZETT
Journal:  Br J Pharmacol Chemother       Date:  1957-06
  4 in total

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