| Literature DB >> 14409220 |
Abstract
The rate of aerobic transformation of glucose-U-C(14) into radioactive amino acids by slices of rat-brain cortex is greatly influenced by the K(+)/Ca(++) ratio in the incubating medium. Protoveratrine has effects on the amino acid pattern resembling that due to an increase in the K(+)/Ca(++) ratio. These effects are antagonized by cocaine and may be correlated with the neurophysiological activities of these drugs.Entities:
Keywords: AMINO ACIDS/metabolism; CEREBRAL CORTEX/metabolism; COCAINE/pharmacology; GLUCOSE/metabolism; VERATRUM/pharmacology
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Year: 1960 PMID： 14409220 DOI： 10.1126/science.131.3398.412
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728