Literature DB >> 144042

Effect of alpha-methyldopa on the pulmonary vascular changes induced by chronic hypoxia in rats.

A J Suggett, J Herget.   

Abstract

1. Groups of young rats were kept in a hypoxic chamber or in air as control animals for 28 days. 2. Hypoxic and control animals were treated with either alpha-methyl-3,4-dihydroxyphenylalanine (alpha-methyldopa) or distilled water. 3. alpha-Methyldopa significantly reduced the increase in pulmonary artery pressure and right ventricular hypertrophy induced by chronic hypoxia and partially prevented the histological changes in the small pulmonary vessels.

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Year:  1977        PMID： 144042     DOI： 10.1042/cs0530397

Source DB:  PubMed          Journal:  Clin Sci Mol Med        ISSN： 0301-0538


  5 in total

Review 1.  Pulmonary hypertension.

Authors:  J R Michael; W R Summer
Journal:  Lung       Date:  1985       Impact factor: 2.584

2.  Continuous inhalation of nitric oxide protects against development of pulmonary hypertension in chronically hypoxic rats.

Authors:  C Kouyoumdjian; S Adnot; M Levame; S Eddahibi; H Bousbaa; B Raffestin
Journal:  J Clin Invest       Date:  1994-08       Impact factor: 14.808

3.  Drugs or oxygen for hypoxic cor pulmonale?

Authors:  P Howard
Journal:  Br Med J (Clin Res Ed)       Date:  1983-10-22

4.  The effect of isoproterenol on the development and recovery of hypoxic pulmonary hypertension. A structural and hemodynamic study.

Authors:  R Fried; L M Reid
Journal:  Am J Pathol       Date:  1985-10       Impact factor: 4.307

5.  The effects of vincristine on platelet aggregation studied by a filter loop technique in the rat.

Authors:  D Bee; E Leach; J F Martin; A J Suggett
Journal:  Br J Pharmacol       Date:  1980-06       Impact factor: 8.739
  5 in total

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