Literature DB >> 14400

Glutamine synthetase: glial localization in brain.

A Martinez-Hernandez, K P Bell, M D Norenberg.   

Abstract

Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, gamma-aminobutyric acid, and ammonia metabolism in brain.

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Year:  1977        PMID： 14400     DOI： 10.1126/science.14400

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  292 in total

Review 1.  Hepatic encephalopathy as a complication of liver disease.

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2.  Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized (1)H and (15)N NMR spectroscopy.

Authors:  Cristina Cudalbu; Bernard Lanz; João M N Duarte; Florence D Morgenthaler; Yves Pilloud; Vladimir Mlynárik; Rolf Gruetter
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3.  Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures.

Authors:  María C Hyzinski-García; Melanie Y Vincent; Renée E Haskew-Layton; Preeti Dohare; Richard W Keller; Alexander A Mongin
Journal:  J Neurochem       Date:  2011-05-19       Impact factor: 5.372

4.  Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength.

Authors:  Gregory C Mathews; Jeffrey S Diamond
Journal:  J Neurosci       Date:  2003-03-15       Impact factor: 6.167

5.  Rabbit retinal organ culture as an in-vitro model of hepatic retinopathy.

Authors:  Heidrun Kuhrt; Michał Walski; Andreas Reichenbach; Jan Albrecht
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2004-02-18       Impact factor: 3.117

6.  Morphological arrangement between astrocytes and trigeminal mesencephalic primary afferent neurons in the rat.

Authors:  J C Copray; R S Liem; J D van Willigen
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

7.  Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy.

Authors:  V Rangroo Thrane; A S Thrane; J Chang; J Chanag; V Alleluia; E A Nagelhus; M Nedergaard
Journal:  Neuroscience       Date:  2012-06-21       Impact factor: 3.590

8.  Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy.

Authors:  Tore Eid; Tih-Shih W Lee; Yue Wang; Edgar Perez; Edgar Peréz; Jana Drummond; Fredrik Lauritzen; Linda H Bergersen; James H Meador-Woodruff; Dennis D Spencer; Nihal C de Lanerolle; Robert E McCullumsmith
Journal:  Epilepsia       Date:  2012-11-13       Impact factor: 5.864

Review 9.  Glutamate transporters in the biology of malignant gliomas.

Authors:  Stephanie M Robert; Harald Sontheimer
Journal:  Cell Mol Life Sci       Date:  2013-11-27       Impact factor: 9.261

10.  Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells.

Authors:  Erika M Palmieri; Alessio Menga; Aurore Lebrun; Douglas C Hooper; D Allan Butterfield; Massimiliano Mazzone; Alessandra Castegna
Journal:  Antioxid Redox Signal       Date:  2016-11-02       Impact factor: 8.401
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