| Literature DB >> 1439788 |
R A Gibbs1, S Taylor, S J Benkovic.
Abstract
The generation of antibodies from a bifunctional cyclic phosphinate transition-state analog provided agents capable of efficiently catalyzing both steps of the overall conversion of a substrate containing an asparaginyl-glycyl sequence through a succinimide intermediate to the products aspartyl-glycyl and the rearranged isoaspartyl-glycyl sequence. This reaction provides a potential means in addition to amide cleavage for the deactivation of protein or peptide biological functions in vivo.Entities:
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Year: 1992 PMID： 1439788 DOI： 10.1126/science.1439788
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728