Literature DB >> 1439581

Isoelectrophoretic characterization of protein antigens present in mycobacterial culture filtrates and recognized by monoclonal antibodies directed against the Mycobacterium bovis BCG antigen 85 complex.

A Drowart1, J De Bruyn, K Huygen, G Damiani, H P Godfrey, M Stelandre, J C Yernault, J P Van Vooren.   

Abstract

Nine monoclonal antibodies (MoAbs) were produced against Mycobacterium bovis BCG antigen 85 complex. Using isoelectric focusing combined with Western (immunoblot) blot analysis, antigenically related proteins could be identified in culture filtrates from M. tuberculosis, M. bovis, M. Kansasii, M. avium, M. xenopi, M. gordonae, M. fortuitum, M. phlei and M. smegmatis. Most of the MoAbs were found to be broadly cross-reactive between the various mycobacterial species, albeit some minor differences were observed. These MoAbs reacted generally, in each species, with different components. One MoAb (VID1-14) was found to be specifically directed only against antigen 85B from M. bovis, M. tuberculosis and M. kansasii.

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Year:  1992        PMID： 1439581     DOI： 10.1111/j.1365-3083.1992.tb03130.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN： 0300-9475            Impact factor:   3.487


  15 in total

1.  Combinatorial use of antibodies to secreted mycobacterial proteins in a host immune system-independent test for tuberculosis.

Authors:  C P Landowski; H P Godfrey; S I Bentley-Hibbert; X Liu; Z Huang; R Sepulveda; K Huygen; M L Gennaro; F H Moy; S A Lesley; M Haak-Frendscho
Journal:  J Clin Microbiol       Date:  2001-07       Impact factor: 5.948

2.  Analysis of the genes encoding the antigen 85 complex and MPT51 from Mycobacterium avium.

Authors:  N Ohara; N Ohara-Wada; H Kitaura; T Nishiyama; S Matsumoto; T Yamada
Journal:  Infect Immun       Date:  1997-09       Impact factor: 3.441

3.  Inhibition of expression of delayed hypersensitivity by neutralizing monoclonal anti-T-cell fibronectin antibody.

Authors:  S Mandy; Z Feng; L S Canfield; K Mandy; X Quan; R A Rowehl; M Y Khan; S K Akiyama; H P Godfrey
Journal:  Immunology       Date:  1994-12       Impact factor: 7.397

4.  Heterologous expression of the Mycobacterium tuberculosis gene encoding antigen 85A in Corynebacterium glutamicum.

Authors:  K Salim; V Haedens; J Content; G Leblon; K Huygen
Journal:  Appl Environ Microbiol       Date:  1997-11       Impact factor: 4.792

5.  Decoration of outer membrane vesicles with multiple antigens by using an autotransporter approach.

Authors:  Maria H Daleke-Schermerhorn; Tristan Felix; Zora Soprova; Corinne M Ten Hagen-Jongman; David Vikström; Laleh Majlessi; Joep Beskers; Frank Follmann; Karin de Punder; Nicole N van der Wel; Thomas Baumgarten; Thang V Pham; Sander R Piersma; Connie R Jiménez; Peter van Ulsen; Jan-Willem de Gier; Claude Leclerc; Wouter S P Jong; Joen Luirink
Journal:  Appl Environ Microbiol       Date:  2014-07-18       Impact factor: 4.792

6.  Mapping of TH1 helper T-cell epitopes on major secreted mycobacterial antigen 85A in mice infected with live Mycobacterium bovis BCG.

Authors:  K Huygen; E Lozes; B Gilles; A Drowart; K Palfliet; F Jurion; I Roland; M Art; M Dufaux; J Nyabenda
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

Review 7.  The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis.

Authors:  H G Wiker; M Harboe
Journal:  Microbiol Rev       Date:  1992-12

8.  Pathophysiology of antigen 85 in patients with active tuberculosis: antigen 85 circulates as complexes with fibronectin and immunoglobulin G.

Authors:  S I Bentley-Hibbert; X Quan; T Newman; K Huygen; H P Godfrey
Journal:  Infect Immun       Date:  1999-02       Impact factor: 3.441

9.  An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines.

Authors:  Wouter S P Jong; Maria H Daleke-Schermerhorn; David Vikström; Corinne M Ten Hagen-Jongman; Karin de Punder; Nicole N van der Wel; Carolien E van de Sandt; Guus F Rimmelzwaan; Frank Follmann; Else Marie Agger; Peter Andersen; Jan-Willem de Gier; Joen Luirink
Journal:  Microb Cell Fact       Date:  2014-11-25       Impact factor: 5.328

10.  Novel human recombinant antibodies against Mycobacterium tuberculosis antigen 85B.

Authors:  Manon Fuchs; Susanne Kämpfer; Saskia Helmsing; Ralf Spallek; Wulf Oehlmann; Wiebke Prilop; Ronald Frank; Stefan Dübel; Mahavir Singh; Michael Hust
Journal:  BMC Biotechnol       Date:  2014-07-17       Impact factor: 2.563
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