Literature DB >> 1438882

Molecular evolution of cyclooxygenase and lipoxygenase.

H Toh1, C Yokoyama, T Tanabe, T Yoshimoto, S Yamamoto.   

Abstract

Four oxygenases of the arachidonic acid cascade (cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase and 15-lipoxygenase) were investigated by the method of computer-assisted sequence comparison. From the calculations, some aspects of evolution and function of these enzymes were revealed. (1) The evolutionary origin of cyclooxygenase was different from that of lipoxygenases. (2) Cyclooxygenase was a distantly related member of a peroxidase family. (3) Enzymes with 12-lipoxygenase activity were created independently twice by gene duplication.

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Year:  1992        PMID： 1438882     DOI： 10.1016/0090-6980(92)90004-d

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  5 in total

1.  Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development.

Authors:  Ulrike Haas; Elisabeth Raschperger; Mats Hamberg; Bengt Samuelsson; Karl Tryggvason; Jesper Z Haeggström
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-05       Impact factor: 11.205

2.  Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

Authors:  D G Tang; Y Q Chen; K V Honn
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

Review 3.  12-lipoxygenases and 12(S)-HETE: role in cancer metastasis.

Authors:  K V Honn; D G Tang; X Gao; I A Butovich; B Liu; J Timar; W Hagmann
Journal:  Cancer Metastasis Rev       Date:  1994-12       Impact factor: 9.264

4.  Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain: Evidence from high-density oligonucleotide arrays and in situ hybridization.

Authors:  Jessica A Mong; Nino Devidze; Donald E Frail; Lawrence T O'Connor; Manjo Samuel; Elena Choleris; Sonoko Ogawa; Donald W Pfaff
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-23       Impact factor: 11.205

Review 5.  Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.

Authors:  Thomas Horn; Susan Adel; Ralf Schumann; Saubashya Sur; Kumar Reddy Kakularam; Aparoy Polamarasetty; Pallu Redanna; Hartmut Kuhn; Dagmar Heydeck
Journal:  Prog Lipid Res       Date:  2014-11-28       Impact factor: 16.195
  5 in total

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