Literature DB >> 1438532

Ornithine decarboxylase as an enzyme target for therapy.

P P McCann1, A E Pegg.   

Abstract

Interest in ornithine decarboxylase (ODC) and the therapeutic effects of its inhibition with the consequent depletion of polyamine biosynthesis has been widespread since the late 1970s and 1980s. This review covers new information about the properties of ODC, recent findings with ODC inhibitors and a discussion of the mechanism of inactivation of ODC by eflornithine. Recent in vivo therapeutic approaches of ODC inhibition are also discussed including: cancer and cancer chemoprevention; autoimmune diseases; polyamines and the blood-brain barrier, ischemia and hyperplasia; the NMDA receptor and modulation by polyamines; hearing loss; African trypanosomiasis; Pneumocystis carinii pneumonia and Cryptosporidium in AIDS; and other infectious diseases/organisms.

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Year:  1992        PMID： 1438532     DOI： 10.1016/0163-7258(92)90032-u

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  41 in total

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4.  Regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in a polyamine auxotrophic cell line.

Authors:  F Svensson; L Persson
Journal:  Mol Cell Biochem       Date:  1996-09-20       Impact factor: 3.396

5.  Modeling of the spatial structure of eukaryotic ornithine decarboxylases.

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Authors:  F Svensson; C Ceriani; E L Wallström; I Kockum; I D Algranati; O Heby; L Persson
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-21       Impact factor: 11.205

8.  Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.

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9.  Polyamine content and drug sensitivities of different clonal lines of Leishmania infantum promastigotes.

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