Literature DB >> 1438205

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.

T Watanabe1, Y Ono, Y Taniyama, K Hazama, K Igarashi, K Ogita, U Kikkawa, Y Nishizuka.   

Abstract

Several lines of CHO cells stably overexpressing protein kinase C (PKC) subspecies to various extents were established by the DNA-mediated transfer. Upon treatment with phorbol 12-myristate 13-acetate, the growth of the cells expressing the PKC-delta subspecies was markedly inhibited, whereas cell lines expressing PKC-alpha, PKC-beta II, and PKC-zeta subspecies were not significantly affected. Flow cytometric analysis indicated that all cell lines overexpressing PKC-delta subspecies accumulated in G2/M phase in response to phorbol 12-myristate 13-acetate. In these arrested cells, dikaryons were predominant, implying that phorbol ester-induced inhibition of cell division is specific to telophase. These results suggest PKC-delta subspecies may play a role in the normal cell cycle progression.

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Year:  1992        PMID： 1438205      PMCID： PMC50297          DOI： 10.1073/pnas.89.21.10159

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

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Journal:  Nature       Date:  1990-04-05       Impact factor: 49.962

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Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

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Authors:  W L Hsiao; G M Housey; M D Johnson; I B Weinstein
Journal:  Mol Cell Biol       Date:  1989-06       Impact factor: 4.272

4.  Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression.

Authors:  P M Choi; K M Tchou-Wong; I B Weinstein
Journal:  Mol Cell Biol       Date:  1990-09       Impact factor: 4.272

5.  Protein kinase C isozyme expression in phorbol ester-sensitive and -resistant EL4 thymoma cells.

Authors:  E C Homan; D E Jensen; J J Sando
Journal:  J Biol Chem       Date:  1991-03-25       Impact factor: 5.157

6.  A mutant protein kinase C that can transform fibroblasts.

Authors:  T Megidish; N Mazurek
Journal:  Nature       Date:  1989-12-14       Impact factor: 49.962

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Authors:  K Mizuno; K Kubo; T C Saido; Y Akita; S Osada; T Kuroki; S Ohno; K Suzuki
Journal:  Eur J Biochem       Date:  1991-12-18

8.  Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein.

Authors:  H Mischak; A Bodenteich; W Kolch; J Goodnight; F Hofer; J F Mushinski
Journal:  Biochemistry       Date:  1991-08-13       Impact factor: 3.162

9.  Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

Authors:  G Urlaub; L A Chasin
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

10.  N-myc disrupts protein kinase C-mediated signal transduction in neuroblastoma.

Authors:  R Bernards
Journal:  EMBO J       Date:  1991-05       Impact factor: 11.598
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  67 in total

1.  Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.

Authors:  H Takaishi; H Konishi; H Matsuzaki; Y Ono; Y Shirai; N Saito; T Kitamura; W Ogawa; M Kasuga; U Kikkawa; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

2.  Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival.

Authors:  Aline Fréville; Isabelle Landrieu; M Adelaida García-Gimeno; Jérôme Vicogne; Muriel Montbarbon; Benjamin Bertin; Alexis Verger; Hadidjatou Kalamou; Pascual Sanz; Elisabeth Werkmeister; Christine Pierrot; Jamal Khalife
Journal:  J Biol Chem       Date:  2011-11-28       Impact factor: 5.157

3.  Fluorescent-responsive synthetic C1b domains of protein kinase Cδ as reporters of specific high-affinity ligand binding.

Authors:  Nami Ohashi; Wataru Nomura; Tetsuo Narumi; Nancy E Lewin; Kyoko Itotani; Peter M Blumberg; Hirokazu Tamamura
Journal:  Bioconjug Chem       Date:  2010-12-22       Impact factor: 4.774

4.  Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy.

Authors:  H Wakasaki; D Koya; F J Schoen; M R Jirousek; D K Ways; B D Hoit; R A Walsh; G L King
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

5.  Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential.

Authors:  C A La Porta; R Comolli
Journal:  Clin Exp Metastasis       Date:  1997-11       Impact factor: 5.150

6.  The 5' untranslated region of protein kinase Cdelta directs translation by an internal ribosome entry segment that is most active in densely growing cells and during apoptosis.

Authors:  Bronwyn C Morrish; Martin G Rumsby
Journal:  Mol Cell Biol       Date:  2002-09       Impact factor: 4.272

7.  Three distinct mechanisms for translocation and activation of the delta subspecies of protein kinase C.

Authors:  S Ohmori; Y Shirai; N Sakai; M Fujii; H Konishi; U Kikkawa; N Saito
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272

8.  Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxide-induced cell transformation: role of protein kinase C.

Authors:  Jagat J Mukherjee; Subodh Kumar
Journal:  Mutat Res       Date:  2009-12-16       Impact factor: 2.433

9.  Protein kinase C isoform expression in CD45RA+ and CD45RO+ T lymphocytes.

Authors:  E Corrigan; D Kelleher; C Feighery; A Long
Journal:  Immunology       Date:  1995-06       Impact factor: 7.397

10.  Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta.

Authors:  Jyoti Srivastava; Katarzyna J Procyk; Xavier Iturrioz; Peter J Parker
Journal:  Biochem J       Date:  2002-11-15       Impact factor: 3.857
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