Literature DB >> 1436715

Thyrotropin-releasing hormone analogue and serotonin interact within the dorsal vagal complex to augment gastric acid secretion.

D M McTigue1, R C Rogers, R L Stephens.   

Abstract

The effects of serotonin (5HT) and a thyrotropin-releasing hormone (TRH) analogue, RX77368, on vagal control of gastric acid secretion were studied. Microinjection of RX77368 (0.66 pmol in 10 nl), but not 5HT (8 pmol in 10 nl), into the dorsal vagal complex (DVC) evoked a significant increase in acid output. When the same doses of RX77368 and 5HT were co-injected, the amount of acid secreted was significantly greater than that due to RX77368 alone. Thus, 5HT and the TRH analogue interact within the DVC to enhance vagal stimulation of acid secretion. The study suggests a possible functional significance of raphe TRH/serotonergic tracts projecting to the DVC.

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Year:  1992        PMID： 1436715     DOI： 10.1016/0304-3940(92)90716-k

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  6 in total

1.  Characterization of the in vitro effects of 5-hydroxytryptamine (5-HT) on identified neurones of the rat dorsal motor nucleus of the vagus (DMV).

Authors:  K N Browning; R A Travagli
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

Review 2.  Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding.

Authors:  Y Taché; H Yang; M Miampamba; V Martinez; P Q Yuan
Journal:  Auton Neurosci       Date:  2006-03-06       Impact factor: 3.145

3.  The peptide TRH uncovers the presence of presynaptic 5-HT1A receptors via activation of a second messenger pathway in the rat dorsal vagal complex.

Authors:  K N Browning; R A Travagli
Journal:  J Physiol       Date:  2001-03-01       Impact factor: 5.182

4.  Gastric vagal motoneuron function is maintained following experimental spinal cord injury.

Authors:  E M Swartz; G M Holmes
Journal:  Neurogastroenterol Motil       Date:  2014-10-15       Impact factor: 3.598

5.  The effect of 5-HT and selective 5-HT receptor agonists and antagonists on rat dorsal vagal preganglionic neurones in vitro.

Authors:  A P Albert; K M Spyer; P A Brooks
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

6.  Activation of the parapyramidal region in the ventral medulla stimulates gastric acid secretion through vagal pathways in rats.

Authors:  H Yang; P Q Yuan; L Wang; Y Taché
Journal:  Neuroscience       Date:  2000       Impact factor: 3.590
  6 in total

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