Literature DB >> 1436659

Differential subcellular distribution of PC1, PC2 and furin in bovine adrenal medulla and secretion of PC1 and PC2 from this tissue.

R Kirchmair1, C Egger, P Gee, R Hogue-Angeletti, R Fischer-Colbrie, A Laslop, H Winkler.   

Abstract

The subcellular distribution of PC1, PC2 and furin was determined in bovine adrenal medulla by immunoblotting of fractions obtained by density gradient centrifugation. PC1 and PC2 were found to be confined to chromaffin granules whereas furin (C-terminal-peptide) was absent from these organelles. Stimulation of bovine adrenal medulla by carbamoylcholine chloride induced the secretion of PC1 and PC2. The secreted enzymes had the same molecular size as PC1 and PC2 present in chromaffin granules.

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Year:  1992        PMID： 1436659     DOI： 10.1016/0304-3940(92)90252-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

Review 1.  Sorting and processing of secretory proteins.

Authors:  P A Halban; J C Irminger
Journal:  Biochem J       Date:  1994-04-01       Impact factor: 3.857

2.  Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.

Authors:  S Benjannet; N Rondeau; L Paquet; A Boudreault; C Lazure; M Chrétien; N G Seidah
Journal:  Biochem J       Date:  1993-09-15       Impact factor: 3.857

Review 3.  The adrenal chromaffin granule: a model for large dense core vesicles of endocrine and nervous tissue.

Authors:  H Winkler
Journal:  J Anat       Date:  1993-10       Impact factor: 2.610

4.  Cell type-specific sorting of neuropeptides: a mechanism to modulate peptide composition of large dense-core vesicles.

Authors:  J Klumperman; S Spijker; J van Minnen; H Sharp-Baker; A B Smit; W P Geraerts
Journal:  J Neurosci       Date:  1996-12-15       Impact factor: 6.167

Review 5.  The chromogranins: their roles in secretion from neuroendocrine cells and as markers for neuroendocrine neoplasia.

Authors:  Steven A Feldman; Lee E Eiden
Journal:  Endocr Pathol       Date:  2003       Impact factor: 3.943

6.  Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells.

Authors:  F Jean; A Basak; N Rondeau; S Benjannet; G N Hendy; N G Seidah; M Chrétien; C Lazure
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

7.  Immunohistochemical Localization of Chromostatin and Pancreastatin, Chromogranin A-Derived Bioactive Peptides, in Normal and Neoplastic Neuroendocrine Tissues.

Authors:  Noriko Kimura; Akihiro Funakoshi; Dominique Aunis; Kayoko Tateishi; Wakako Miura; Hiroshi Nagura
Journal:  Endocr Pathol       Date:  1995       Impact factor: 3.943
  7 in total

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