Literature DB >> 14348192

REACTION OF THE CARCINOGEN DIMETHYLNITROSAMINE WITH PROTEINS AND WITH THIOL COMPOUNDS IN THE INTACT ANIMAL.

V M CRADDOCK.   

Abstract

1. [(14)C]Dimethylnitrosamine was administered to rats, and the formation of free and protein-bound S-methylcysteine was investigated. 2. Very little S-methylcysteine was found in liver acid-soluble fraction, in liver protein or in urine. 3. The methylhistidines formed in liver protein were found to have largely disappeared by 6 days after injection of dimethylnitrosamine. 4. The significance of these results in the carcinogenic action of dimethylnitrosamine is discussed.

Entities:  

Keywords:  ALKYLATION; CARCINOGENS; CHROMATOGRAPHY; EXPERIMENTAL LAB STUDY; FORMATES; HOMOGENATES; ION EXCHANGE RESINS; NEOPLASM ETIOLOGY; NITROSAMINES; PHARMACOLOGY; PROTEINS; RATS; SILVER; SULFHYDRYL COMPOUNDS; TOXICOLOGIC REPORT; URINE

Mesh：

Substances：

Year:  1965        PMID： 14348192      PMCID： PMC1206513          DOI： 10.1042/bj0940323

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

1.  ON THE ISOLATION AND IDENTIFICATION OF S-METHYLCYSTEINE FROM HUMAN URINE.

Authors:  F TOMINAGA; S KOBAYASHI; I MUTA; H TAKEI; M ICHINOSE
Journal:  J Biochem       Date:  1963-09       Impact factor: 3.387

2.  STUDIES OF THE MODE OF ACTION OF ALKYLATING AGENTS. VI. THE METABOLISM OF BIS-2-CHLOROETHYLSULPHIDE (MUSTARD GAS) AND RELATED COMPOUNDS.

Authors:  J J ROBERTS; G P WARWICK
Journal:  Biochem Pharmacol       Date:  1963-12       Impact factor: 5.858

3.  STUDIES OF THE MODE OF ACTION OF TUMOUR-GROWTH-INHIBITING ALKYLATING AGENTS. V. THE METABOLISM OF 2-CHLOROETHYLARYLAMINES.

Authors:  J J ROBERTS; G P WARWICK
Journal:  Biochem Pharmacol       Date:  1963-12       Impact factor: 5.858

4.  The detection of metabolic products from dimethylnitrosamine in rats and mice.

Authors:  D F HEATH; A DUTTON
Journal:  Biochem J       Date:  1958-12       Impact factor: 3.857

5.  Toxic liver injury; the metabolism of dimethylnitrosamine in vitro.

Authors:  P N MAGEE; M VANDEKAR
Journal:  Biochem J       Date:  1958-12       Impact factor: 3.857

6.  Microsomal N-demethylation and the effect of the hepatic carcinogen dimethylnitrosamine on amino acid incorporation into the proteins of rat livers and hepatomas.

Authors:  J A BROUWERS; P EMMELOT
Journal:  Exp Cell Res       Date:  1960-04       Impact factor: 3.905

7.  Mode of action of alkylating agents: formation of S-ethylcysteine from ethyl methanesulphonate in vivo.

Authors:  J J ROBERTS; G P WARWICK
Journal:  Nature       Date:  1957-06-08       Impact factor: 49.962

8.  3-Methylhistidine, a new amino acid from human urine.

Authors:  H H TALLAN; W H STEIN; S MOORE
Journal:  J Biol Chem       Date:  1954-02       Impact factor: 5.157

9.  Estimation of amino acids by ninhydrin.

Authors:  E C COCKING; E W YEMM
Journal:  Biochem J       Date:  1954-06-19       Impact factor: 3.857

10.  Carcinogenic activity of a series of reactive lactones and related substances.

Authors:  F DICKENS; H E JONES
Journal:  Br J Cancer       Date:  1961-03       Impact factor: 7.640
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  3 in total

1.  Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.

Authors:  Claudia R Oliva; Susan E Nozell; Anne Diers; Samuel G McClugage; Jann N Sarkaria; James M Markert; Victor M Darley-Usmar; Shannon M Bailey; G Yancey Gillespie; Aimee Landar; Corinne E Griguer
Journal:  J Biol Chem       Date:  2010-09-24       Impact factor: 5.157

2.  Methylation of nuclear proteins by dimethylnitrosamine and by methionine in the rat in vivo.

Authors:  C Turberville; V M Craddock
Journal:  Biochem J       Date:  1971-10       Impact factor: 3.857

3.  Analysis of bases of rat-liver nucleic acids after administration of the carcinogen dimethylnitrosamine.

Authors:  V M Craddock; P N Magee
Journal:  Biochem J       Date:  1966-09       Impact factor: 3.857
  3 in total

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