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Literature DB >> 14340055

EFFECTS OF TETRAZOLIUM SALTS ON OXIDATIVE PHOSPHORYLATION IN RAT-LIVER MITOCHONDRIA.

Abstract

1. The effects of five different tetrazolium salts on oxidative phosphorylation in rat-liver mitochondria have been investigated. 2. In all cases the mitochondria were uncoupled by very low concentrations of the tetrazolium salts. Further, the transition from a system just exhibiting respiratory control to one in which the mitochondria were totally uncoupled has been shown to occur over very small concentration ranges of the tetrazolium salts. 3. The effectiveness of the five tetrazolium salts as uncoupling agents is discussed in the light of their standard electrode potentials and effectiveness as electron acceptors in dehydrogenase-linked reactions.

Entities: Chemical Disease Species

Keywords: EXPERIMENTAL LAB STUDY; HYDROXYBUTYRATES; LIVER CYTOLOGY; LIVER FUNCTION; METABOLISM; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; PHARMACOLOGY; RATS; SUCCINATES; TETRAZOLIUM SALTS

Mesh：

Substances：

Year: 1965 PMID： 14340055 PMCID： PMC1206599 DOI： 10.1042/bj0940651

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

7 in total

5. Studies on the electron transport system. 28. The mode of reduction of tetrazolium salts by beef heart mitochondria; role of coenzyme Q and other lipids.

Authors: R L LESTER; A L SMITH
Journal: Biochim Biophys Acta Date: 1961-03-04

6. Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization.

Authors: B CHANCE; G R WILLIAMS
Journal: J Biol Chem Date: 1955-11 Impact factor: 5.157

7. Oxidative phosphorylation.

Authors: A L LEHNINGER; C L WADKINS
Journal: Annu Rev Biochem Date: 1962 Impact factor: 23.643

7 in total

6 in total

EFFECTS OF TETRAZOLIUM SALTS ON OXIDATIVE PHOSPHORYLATION IN RAT-LIVER MITOCHONDRIA.

1. STUDIES ON SUCCINATE-TETRAZOLIUM REDUCTASE SYSTEMS. III. POINTS OF COUPLING OF FOUR DIFFERENT TETRAZOLIUM SALTS.

2. Sites of electron transfer to tetrazolium salts in the succinoxidase system.

3. Reduced diphosphopyridine nucleotide neotetrazolium reductase.

4. The constitution of the respiratory chain in animal tissues.

5. Studies on the electron transport system. 28. The mode of reduction of tetrazolium salts by beef heart mitochondria; role of coenzyme Q and other lipids.

6. Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization.

7. Oxidative phosphorylation.

1. The hepatotoxic action of allyl formate.

2. The use of tetrazolium salts in the histochemical demonstration of succinic dehydrogenase activity in plant tissues.

3. Tetrazolium salt: antagonism of acetylcholine-induced response on frog's rectus.

4. The reduction of tetrazolium salts by plant mitochondria.

5. Some effects of tetrazolium salt on the metabolism of mitochondria isolated from Jerusalem artichoke tubers.

6. The action of paraquat and diquat on the respiration of liver cell fractions.