Literature DB >> 1433417

Effect of chronic hypoxia on fibronectin in plasma, bronchoalveolar lavage fluid and liver of rats.

Y J Xu1, T Abe, K Shiraishi, M Motomiya.   

Abstract

The present study was undertaken to measure fibronectin (FN) concentration in plasma and bronchoalveolar lavage fluid (BALF) with an enzyme linked immunosorbent assay (ELISA) method, to observe the distribution of FN in liver with an immunohistochemical stain method and to investigate the effect of chronic normobaric hypoxia on them in experimental rats. The results showed that chronic hypoxia caused a significant decrease in plasma FN concentration while BALF FN concentration and the distribution of FN in the liver were not significantly affected, suggesting that the change in FN in the lower respiratory tract can not be reflected by the change in plasma FN concentration and that the decrease in plasma FN concentration can not be attributed to the change in liver FN secretion. The decrease in plasma FN concentration may lead to a decrease in the defence ability of the body and may contribute to the development of hypercoagulability observed in some patients with chronic hypoxia.

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Year:  1992        PMID： 1433417     DOI： 10.1007/bf02887791

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  10 in total

1.  An immunocytochemical method for quantification of lung tissue fibronectin.

Authors:  Y M Bellay; A M Dayer; J E Grossman; J A Will
Journal:  Proc Soc Exp Biol Med       Date:  1988-06

2.  Plasma fibronectin in healthy newborn infants: respiratory distress syndrome and perinatal asphyxia.

Authors:  M C Yoder; S D Douglas; J Gerdes; J Kline; R A Polin
Journal:  J Pediatr       Date:  1983-05       Impact factor: 4.406

3.  Enzyme-linked immunoassay (ELISA) for connective tissue components.

Authors:  S I Rennard; R Berg; G R Martin; J M Foidart; P G Robey
Journal:  Anal Biochem       Date:  1980-05-01       Impact factor: 3.365

4.  Hyaluronan (hyaluronic acid) in bronchoalveolar lavage fluid during the development of bleomycin-induced alveolitis in the rat.

Authors:  O Nettelbladt; R Hällgren
Journal:  Am Rev Respir Dis       Date:  1989-10

5.  Immunoelectron microscopic observations on the localization of fibronectin in normal human lung.

Authors:  K Takusagawa; N Asoo; T Sato; H Nagai; M Motomiya; K Konno
Journal:  Tohoku J Exp Med       Date:  1986-10       Impact factor: 1.848

6.  Reduction of chronic hypoxic pulmonary hypertension in the rat by an inhibitor of collagen production.

Authors:  J S Kerr; C L Ruppert; C A Tozzi; J A Neubauer; H M Frankel; S Y Yu; D J Riley
Journal:  Am Rev Respir Dis       Date:  1987-02

7.  Measurement of plasma fibronectin in patients who develop the adult respiratory distress syndrome.

Authors:  R J Maunder; J M Harlan; P E Pepe; S Paskell; C J Carrico; L D Hudson
Journal:  J Lab Clin Med       Date:  1984-10

8.  Fibronectin levels in normal subjects and patients admitted to a respiratory intensive care unit.

Authors:  L R Purves; G Brown; N Linton
Journal:  S Afr Med J       Date:  1982-05-15

9.  Deposition of plasma fibronectin in tissues.

Authors:  E Oh; M Pierschbacher; E Ruoslahti
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

Review 10.  Fibronectins: multifunctional modular glycoproteins.

Authors:  R O Hynes; K M Yamada
Journal:  J Cell Biol       Date:  1982-11       Impact factor: 10.539
  10 in total

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