| Literature DB >> 1433404 |
L B Hinshaw1, T E Emerson, F B Taylor, A C Chang, M Duerr, G T Peer, D J Flournoy, G L White, S D Kosanke, C K Murray.
Abstract
A successful experimental treatment for gram-positive sepsis to our knowledge has not been achieved. The objectives of this study were to develop a nonhuman primate model of lethal gram-positive sepsis employing the micro-organism Staphylococcus aureus and to determine the efficacy of treatment using monoclonal antibody (MAb) to tumor necrosis factor alpha (TNF). The antibody was administered intravenously, 15 mg/kg, 30 minutes after the beginning of a 2-hour infusion of S. aureus, 4 x 10(10) colony forming units/kilogram. The baboons infused with S. aureus demonstrated the release of the cytokines TNF and interleukin-6 (IL-6), but endotoxin was not observed in the plasma at any time. Treatment with antibody to TNF abolished the rise in serum TNF levels and reduced the increased levels of IL-6. Treatment with MAb to TNF prevented multiple organ failure and achieved permanent (> 7 day) survival of all baboons.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1433404
Source DB: PubMed Journal: J Trauma ISSN： 0022-5282