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Literature DB >> 14333550

KINETICS OF NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENATION BY HUMAN PLACENTA.

Abstract

1. Measurements of kinetic constants for a purified preparation of human-placenta oestradiol dehydrogenase have been made. 2. These constants have been compared with similar measurements made on crude ammonium sulphate precipitates of human-placenta homogenates. The comparison indicates that nearly half of the observed nicotinamide nucleotide-transhydrogenation activity in the crude preparations is due to a specific oestrogen-dependent transhydrogenase. 3. The remainder of the observed activity results from a substrate-mediated transhydrogenation catalysed by the oestradiol-dehydrogenase activities present in the preparation.

Entities: Chemical Species

Keywords: BIOCHEMISTRY; CATALYSIS; ESTRADIOL; ESTRONE; EXPERIMENTAL LAB STUDY; KINETICS; NAD; NADP; OXIDOREDUCTASES; PLACENTA; SPECTROPHOTOMETRY

Mesh：

Substances：

Year: 1965 PMID： 14333550 PMCID： PMC1215188 DOI： 10.1042/bj0950150

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

13 in total

1. A histochemical study of the oxidation of 17 -estradiol in human term placenta at different incubation conditions. An investigation with the polyvinyl alcohol method.

Authors: S I Mellgren; A Eide
Journal: Histochemie Date: 1972

2. The susceptibility of N-acetyl-S-alkyl- and N-acetyl-S-aryl-cysteine ethyl esters to chymotryptic hydrolysis.

Authors: A P Damoglou; H Lindley; I W Stapleton
Journal: Biochem J Date: 1970-07 Impact factor: 3.857

2 in total

KINETICS OF NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENATION BY HUMAN PLACENTA.

1. ESTROGEN-DEPENDENT PYRIDINE NUCLEOTIDE TRANSHYDROGENASE OF HUMAN MYOMETRIUM.

2. Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver.

3. Statistical estimations in enzyme kinetics.

4. Glutamic dehydrogenase. III. The order of substrate addition in the enzymatic reaction.

5. Purification of a 17beta-hydroxysteroid dehydrogenase of human placenta and studies on its transhydrogenase function.

6. Human placental estradiol-17 beta dehydrogenase. II. Kinetics and substrate specificities.

7. A mammalian 3alpha-hydroxysteroid dehydrogenase.

8. Estrogen-sensitive isocitric dehydrogenase.

9. ON A COENZYMATIC FUNCTION OF ESTRADIOL-17beta.

10. 3 alpha-Hydroxysteroids as coenzymes of hydrogen transfer between di- and triphosphopyridine nucleotides.

1. A histochemical study of the oxidation of 17 -estradiol in human term placenta at different incubation conditions. An investigation with the polyvinyl alcohol method.

2. The susceptibility of N-acetyl-S-alkyl- and N-acetyl-S-aryl-cysteine ethyl esters to chymotryptic hydrolysis.