Literature DB >> 1433271

Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.

N L Haigwood1, L Misher, S M Chin, M Blair, V Planelles, C J Scandella, K S Steimer, M B Gardner, T Yilma, V M Hirsch.   

Abstract

Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.

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Year:  1992        PMID： 1433271

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  5 in total

1.  Comparative efficacy of recombinant modified vaccinia virus Ankara expressing simian immunodeficiency virus (SIV) Gag-Pol and/or Env in macaques challenged with pathogenic SIV.

Authors:  I Ourmanov; C R Brown; B Moss; M Carroll; L Wyatt; L Pletneva; S Goldstein; D Venzon; V M Hirsch
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

2.  Identification of the V1 region as a linear neutralizing epitope of the simian immunodeficiency virus SIVmac envelope glycoprotein.

Authors:  E Jurkiewicz; G Hunsmann; J Schäffner; T Nisslein; W Lüke; H Petry
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

3.  Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity.

Authors:  C C LaBranche; T L Hoffman; J Romano; B S Haggarty; T G Edwards; T J Matthews; R W Doms; J A Hoxie
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

4.  Induction of antibody-mediated neutralization in SIVmac239 by a naturally acquired V3 mutation.

Authors:  Seth A Faith; Yingyun Wu; David Kuhrt; Jonathan D Steckbeck; Jodi K Craigo; Janice E Clements; Kelly Stefano Cole
Journal:  Virology       Date:  2010-02-11       Impact factor: 3.616

5.  Immune response of rhesus macaques to recombinant simian immunodeficiency virus gp130 does not protect from challenge infection.

Authors:  L D Giavedoni; V Planelles; N L Haigwood; S Ahmad; J D Kluge; M L Marthas; M B Gardner; P A Luciw; T D Yilma
Journal:  J Virol       Date:  1993-01       Impact factor: 5.103
  5 in total

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