Literature DB >> 1433270

Detection of simian immunodeficiency virus DNA in macrophages from infected rhesus macaques.

R E Unger1, M L Marthas, A A Lackner, E Pratt-Lowe, B L Lohman, K Van Rompay, P A Luciw.   

Abstract

We have examined the frequency of infection of monocyte-derived and alveolar macrophages isolated from rhesus macaques inoculated with simian immunodeficiency virus (SIVmac) utilizing a semiquantitative PCR methodology. Animals were inoculated with either pathogenic (SIVmac239) or nonpathogenic (SIVmac1A11) molecularly cloned viruses of SIVmac, or with uncloned pathogenic SIVmacBIOL. The frequency of SIV DNA in macrophages was highest early after infection and at terminal stages of disease, whereas during the asymptomatic period, SIV DNA was present at very low levels in macrophages.

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Year:  1992        PMID： 1433270

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  11 in total

1.  Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239.

Authors:  C J Miller; M B McChesney; X Lü; P J Dailey; C Chutkowski; D Lu; P Brosio; B Roberts; Y Lu
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

2.  Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251.

Authors:  X Lü; H Kiyono; D Lu; S Kawabata; J Torten; S Srinivasan; P J Dailey; J R McGhee; T Lehner; C J Miller
Journal:  AIDS       Date:  1998-01-01       Impact factor: 4.177

3.  Vaginal transmission of chimeric simian/human immunodeficiency viruses in rhesus macaques.

Authors:  Y Lu; P Brosio; M Lafaile; J Li; R G Collman; J Sodroski; C J Miller
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

4.  Simian immunodeficiency virus infection of CD8+ lymphocytes in vivo.

Authors:  G A Dean; G H Reubel; N C Pedersen
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

5.  Retention of viral infectivity after extensive mutation of the highly conserved immunodominant domain of the feline immunodeficiency virus envelope.

Authors:  G Pancino; P Sonigo
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

6.  Monocyte maturation controls expression of equine infectious anemia virus.

Authors:  W Maury
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

7.  Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia.

Authors:  C J Miller; M Marthas; J Torten; N J Alexander; J P Moore; G F Doncel; A G Hendrickx
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

8.  Viral factors determine progression to AIDS in simian immunodeficiency virus-infected newborn rhesus macaques.

Authors:  M L Marthas; K K van Rompay; M Otsyula; C J Miller; D R Canfield; N C Pedersen; M B McChesney
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

9.  Simian immunodeficiency virus (SIV) infection of infant rhesus macaques as a model to test antiretroviral drug prophylaxis and therapy: oral 3'-azido-3'-deoxythymidine prevents SIV infection.

Authors:  K K Van Rompay; M L Marthas; R A Ramos; C P Mandell; E K McGowan; S M Joye; N C Pedersen
Journal:  Antimicrob Agents Chemother       Date:  1992-11       Impact factor: 5.191

10.  Viral determinants of simian immunodeficiency virus (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac.

Authors:  M L Marthas; R A Ramos; B L Lohman; K K Van Rompay; R E Unger; C J Miller; B Banapour; N C Pedersen; P A Luciw
Journal:  J Virol       Date:  1993-10       Impact factor: 5.103
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