| Literature DB >> 14331187 |
Abstract
White blood cell preparations from patients with chronic myelocytic leukemia have more S-adenosylmethionine, an important metabolic intermediate, than normal peripheral white cells or thoracic-duct lymphocytes. The previously reported elevation of cyanocobalamine (vitamin B(l2)) in the serum of patients with this disease is corroborated. The possible usefulness of methylation antimetabolites in cancer chemotherapy is suggested.Entities:
Keywords: ANTIMETABOLITES; BIOCHEMISTRY; DRUG THERAPY; LEUKEMIA, MYELOCYTIC; LYMPHOCYTES; METHIONINE; NUCLEOSIDES; VITAMIN B 12
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Year: 1965 PMID： 14331187 DOI： 10.1126/science.149.3684.644
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728